Rhabdomyolysis causes: Difference between revisions
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*[[Surgery]] | *[[Surgery]] | ||
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*Electric current | *[[Electric current]] | ||
*Extreme physical exertion (although most heavy exercise does not cause kidney damage)<ref>{{cite journal |author=Clarkson P, Kearns A, Rouzier P, Rubin R, Thompson P |title=Serum creatine kinase levels and renal function measures in exertional muscle damage |journal=Med Sci Sports Exerc |volume=38 |issue=4 |pages=623-7 |year=2006 |pmid=16679975}}</ref> | *Extreme physical exertion (although most heavy exercise does not cause kidney damage)<ref>{{cite journal |author=Clarkson P, Kearns A, Rouzier P, Rubin R, Thompson P |title=Serum creatine kinase levels and renal function measures in exertional muscle damage |journal=Med Sci Sports Exerc |volume=38 |issue=4 |pages=623-7 |year=2006 |pmid=16679975}}</ref> | ||
*High [[fever]] or [[hyperthermia]] | *High [[fever]] or [[hyperthermia]] | ||
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*[[Alcoholic beverage | *[[Alcohol|Alcoholic beverage]] | ||
*[[Anoxia]] of the muscle (e.g., [[Bywaters' syndrome]], toxin- and drug-related) | *[[Anoxia]] of the muscle (e.g., [[Bywaters' syndrome]], toxin- and drug-related) | ||
*[[Antibiotics]] | *[[Antibiotics]] | ||
*Any drug that directly or indirectly impairs the production or use of [[adenosine triphosphate]] (ATP) by skeletal muscle, or increases energy requirements so as to exceed ATP production, can cause rhabdomyolysis.<ref name="pmid17344731">{{cite journal |author=Larbi EB |title=Drug-induced rhabdomyolysis |journal=Annals of Saudi medicine |volume=18 |issue=6 |pages=525–30 |year=1998 |pmid=17344731 |doi= |url=http://www.kfshrc.edu.sa/annals/186/98-069.html}}</ref> | *Any drug that directly or indirectly impairs the production or use of [[adenosine triphosphate]] (ATP) by skeletal muscle, or increases energy requirements so as to exceed ATP production, can cause rhabdomyolysis.<ref name="pmid17344731">{{cite journal |author=Larbi EB |title=Drug-induced rhabdomyolysis |journal=Annals of Saudi medicine |volume=18 |issue=6 |pages=525–30 |year=1998 |pmid=17344731 |doi= |url=http://www.kfshrc.edu.sa/annals/186/98-069.html}}</ref> | ||
*Certain mushrooms like ''[[Tricholoma equestre]]'' | *Certain mushrooms like ''[[Tricholoma equestre]]'' | ||
*Electrolyte abnormalities | *[[Electrolyte abnormalities]] | ||
*Endocrinopathy | *[[Endocrinopathy]] | ||
*First-generation H1-receptor antagonists (e.g., [[diphenhydramine]]) | *[[H1 antagonist|First-generation H1-receptor antagonists (e.g., [[diphenhydramine]]) | ||
*Heritable muscle enzyme deficiencies | *Heritable muscle enzyme deficiencies | ||
*[[Metabolic disorder]]s, | *[[Metabolic disorder]]s, | ||
*Skeletal muscle | *[[Skeletal muscle relaxant]] that are consumed in overdose are rarely associated with this condition.<ref name="pmid16846511">{{cite journal |author=Chabria SB |title=Rhabdomyolysis: a manifestation of cyclobenzaprine toxicity |journal=Journal of occupational medicine and toxicology (London, England) |volume=1 |issue= |pages=16 |year=2006 |pmid=16846511 |doi=10.1186/1745-6673-1-16 |url=http://www.occup-med.com/content/1/1/16}}</ref> | ||
*[[Statin]] | *[[Statin]] | ||
*Various animal toxins | *Various animal toxins | ||
Revision as of 15:19, 14 November 2016
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Rhabdomyolysis Microchapters |
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Rhabdomyolysis causes On the Web |
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American Roentgen Ray Society Images of Rhabdomyolysis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Injuries leading to rhabdomyolysis can be due to mechanical, physical, and chemical causes.
Causes
| Mechanical Causes | Physical causes | Chemical causes |
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Causes by Pathophysiology
| Rhadomyolysis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traumatic or Muscle Compression | Non - Traumatic | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Non-Traumatic Exertional | Non-Traumatic Non-Exertional | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Non - Traumatic Exertional Rhadomyolysis in a Normal Muscle | Non - Traumatic Exertional Rhadomyolysis in an Abnormal Muscle | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ❑Crush Injury ❑Coma ❑Post Ictal state ❑Post - Operative Surgical trauma ❑Electrical Injury ❑Compartment Syndrome ❑Immbilizaion | ❑Exertional Heat Stroke ❑Sickle Cell Trait ❑Hyperkinetic States Such as *Grand-mal Seizures *Delirium Tremens *Psychotic agitation *Amphetamine Overdose | ❑Drugs and toxins ❑Infections ❑Electrolyte abnormalities ❑Endocrinopathies ❑Inflammatory myopathies ❑Miscellaneous | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Metabolic myopathies | Mitochondrial myopathies | Malignant hyperthermia | Neuroleptic malignant syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Metabolic myopathies | Mitochondrial myopathies | Malignant hyperthermia | Neuroleptic malignant syndrome |
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Disorders of glycogenolysis
Disorders of glycolysis
Disorders of lipid metabolism
Disorders of purine metabolism
Other defects
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Volatile anesthetic agent
Depolarising Neuro-Muscular Blocker
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Neuroleptics
Antiemetic agents
Anti Parkison drug withdrawl
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| Drugs and toxins | Infections | Electrolyte abnormalities | Endocrinopathies | Inflammatory myopathies | Miscellaneous |
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DRUGS CAUSING DIRECT MYOTOXICITY
DRUGS CAUSING AN IMMUNOLOGICALLY MEDIATED MYOPATHY
Toxins
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Viral infections
Bacterial infections
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Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Acetaminophen and Oxycodone, Cytarabine, Diphenhydramine, Entacapone, Felbamate, Iodixanol, Ioxilan, Isotretinoin, lamivudine, Sorafenib, Sulfasalazine, Trospium, trientine |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
References
- ↑ Clarkson P, Kearns A, Rouzier P, Rubin R, Thompson P (2006). "Serum creatine kinase levels and renal function measures in exertional muscle damage". Med Sci Sports Exerc. 38 (4): 623–7. PMID 16679975.
- ↑ Larbi EB (1998). "Drug-induced rhabdomyolysis". Annals of Saudi medicine. 18 (6): 525–30. PMID 17344731.
- ↑ Chabria SB (2006). "Rhabdomyolysis: a manifestation of cyclobenzaprine toxicity". Journal of occupational medicine and toxicology (London, England). 1: 16. doi:10.1186/1745-6673-1-16. PMID 16846511.