Differentiating Churg-Strauss syndrome from other diseases: Difference between revisions
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==Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases== | ==Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases== | ||
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943 }} </ref> | Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943 }} </ref> | ||
{| class="wikitable" | |||
! colspan="4" |Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings | |||
|- | |||
| | |||
|Eosinophilic granulomatosis with polyangiitis | |||
|Granulomatosis with polyangiitis | |||
|Microscopic polyangiitis | |||
|- | |||
|Cytoplasmic ANCA (cANCA) | |||
| | |||
|90% positive | |||
| | |||
|- | |||
|Perinuclear ANCA (pANCA) | |||
|30 to 40% positive | |||
| | |||
|60 to 80% positive | |||
|- | |||
|Myeloperoxidase antigen | |||
|† | |||
| | |||
|† | |||
|- | |||
|Proteinase 3 antigen | |||
| | |||
|† | |||
| | |||
|} | |||
===Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases=== | |||
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause pulmonary eosinophilia and perinuclear anti-neutrophil cytoplasmic antibodies (ANCA) such as: | |||
===Pulmonary eosinophilia=== | |||
* Parasitic infections | |||
* Drugs | |||
* Allergic bronchopulmonary aspergillosis | |||
===Perinuclear ANCA=== | |||
* Cystic Fibrosis | |||
* Bronchogenic carcinoma | |||
* Inflammatory bowel disease | |||
* Sclerosing cholangitis | |||
* Myeloproliferative disorders | |||
* Systemic lupus erythematosis | |||
* Rheumatoid arthritis | |||
==References== | ==References== | ||
Revision as of 14:20, 21 November 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Eosinophilic granulomatosis with polyangiits must be differentiated from other diseases that can cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.[1]
Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.[1]
| Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings | |||
|---|---|---|---|
| Eosinophilic granulomatosis with polyangiitis | Granulomatosis with polyangiitis | Microscopic polyangiitis | |
| Cytoplasmic ANCA (cANCA) | 90% positive | ||
| Perinuclear ANCA (pANCA) | 30 to 40% positive | 60 to 80% positive | |
| Myeloperoxidase antigen | † | † | |
| Proteinase 3 antigen | † | ||
Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause pulmonary eosinophilia and perinuclear anti-neutrophil cytoplasmic antibodies (ANCA) such as:
Pulmonary eosinophilia
- Parasitic infections
- Drugs
- Allergic bronchopulmonary aspergillosis
Perinuclear ANCA
- Cystic Fibrosis
- Bronchogenic carcinoma
- Inflammatory bowel disease
- Sclerosing cholangitis
- Myeloproliferative disorders
- Systemic lupus erythematosis
- Rheumatoid arthritis
References
- ↑ 1.0 1.1 Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.