Microscopic polyangiitis differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Microscopic polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Eosinophilic granulomatosis with polynagiitis. | |||
== Differentiating Microscopic polyangiitis for other diseases == | |||
Microscopic polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Eosinophilic granulomatosis with polyangiitis and Granulomatosis with polyangiitis. | |||
{| class="wikitable" | |||
! colspan="4" |Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings | |||
|- | |||
| | |||
|Eosinophilic granulomatosis with polyangiitis | |||
|Granulomatosis with polyangiitis | |||
|Microscopic polyangiitis | |||
|- | |||
|Cytoplasmic ANCA (cANCA) | |||
| | |||
|90% positive | |||
| | |||
|- | |||
|Perinuclear ANCA (pANCA) | |||
|30 to 40% positive | |||
| | |||
|60 to 80% positive | |||
|- | |||
|Myeloperoxidase antigen | |||
|40% sensitivity | |||
|10% sensitivity | |||
|30% sensitivity | |||
|- | |||
|Proteinase 3 antigen | |||
|<5% sensitivity | |||
|70-80% sensitivity | |||
|60% sensitivity | |||
|} | |||
===Differentiating Granulomatosis with polyangiitis from other Diseases=== | |||
Microscopic polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, pyrexia, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis and include:<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943 }}</ref> | |||
*mononeuritis multiplex | |||
*venous thrombosis | |||
*necrotizing vasculitis of small-sized vessels | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 15:53, 1 December 2016
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Microscopic polyangiitis Microchapters |
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Differentiating Microscopic polyangiitis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Microscopic polyangiitis differential diagnosis On the Web |
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American Roentgen Ray Society Images of Microscopic polyangiitis differential diagnosis |
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Risk calculators and risk factors for Microscopic polyangiitis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Microscopic polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Eosinophilic granulomatosis with polynagiitis.
Differentiating Microscopic polyangiitis for other diseases
Microscopic polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Eosinophilic granulomatosis with polyangiitis and Granulomatosis with polyangiitis.
| Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings | |||
|---|---|---|---|
| Eosinophilic granulomatosis with polyangiitis | Granulomatosis with polyangiitis | Microscopic polyangiitis | |
| Cytoplasmic ANCA (cANCA) | 90% positive | ||
| Perinuclear ANCA (pANCA) | 30 to 40% positive | 60 to 80% positive | |
| Myeloperoxidase antigen | 40% sensitivity | 10% sensitivity | 30% sensitivity |
| Proteinase 3 antigen | <5% sensitivity | 70-80% sensitivity | 60% sensitivity |
Differentiating Granulomatosis with polyangiitis from other Diseases
Microscopic polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, pyrexia, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis and include:[1]
- mononeuritis multiplex
- venous thrombosis
- necrotizing vasculitis of small-sized vessels
References
- ↑ Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.