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==Symptoms==
==Symptoms==
{| class="wikitable"
! colspan="2" |Brucellosis
|-
|Acute brucellosis
|Acute brucellosis may begin with mild [[flu]]-like symptoms, or symptoms such as:<ref>Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.</ref><ref>Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.</ref><ref>Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.</ref><ref>Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.</ref><ref>Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.</ref><ref>Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.</ref><ref>Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.</ref><ref>Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.</ref><ref>Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.</ref><ref>Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.</ref>
Systemic symptoms
*[[Undulant fever]]
**High fever spikes usually occur every afternoon
*[[Night sweats]]
**Often with characteristic smell, likened to wet hay
*[[Chills]]
*[[Fatigue]]
*[[Loss of appetite]]
*[[Weakness]]
*[[Weight loss]]
[[Clinical depression|Depression]]
Focal organ wise symptoms:
* Muscuoskeletal: Joint pain(Commonly in low back and larger joints of lower limbs)
* Genitourinary: Pain in the genital region and increase in frequency of urination/burning senation while passing urine(2 to 20 percent of cases)
* Pulmonary: Cough, chest pain, difficulty in breathing(pulmonary involvement present upto 7 percent of patients)
* Gastrointestinal: Abdominal pain and symptoms of [[hepatitis]] can be present in 3-6 percent of presenting patients
* Neurological: Headache, confusion or altered sensorium(meningoencephalitits), loss of sensation(radiculopathies) can be present in 2-7 percent of patients
* Cardiacvascular: Chest pain is presenting rare cardiovascular feature in brucellosis
* Ocular: Difficulty in vision and Dimenision of vision
* Dermatology: Rash, ulcer or tender swelling can present with brucellosis upto 10 percent of patient
|-
|Relapse
|
|-
|Chronic Brucellosis
|Presence of clinical manifestation for more then one year after established diagnosis of brucellosis is considered as chronic brucellosis.
Clincial manifestations include:
Uveitis: patients complains of difficulty of vision
Spondylitis, osteomyelitis, Arthralgias: patients complains of pain in joints or joint movement
Intermittent sweating
|}


==References==
==References==

Revision as of 15:44, 4 January 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Danitza Lukac

Overview

Symptoms of brucellosis include undulant fever, night sweats (with characteristic smell, likened to wet hay), and joint pain.[1]

Symptoms

Brucellosis
Acute brucellosis Acute brucellosis may begin with mild flu-like symptoms, or symptoms such as:[2][3][4][5][6][7][8][9][10][11]

Systemic symptoms

Depression

Focal organ wise symptoms:

  • Muscuoskeletal: Joint pain(Commonly in low back and larger joints of lower limbs)
  • Genitourinary: Pain in the genital region and increase in frequency of urination/burning senation while passing urine(2 to 20 percent of cases)
  • Pulmonary: Cough, chest pain, difficulty in breathing(pulmonary involvement present upto 7 percent of patients)
  • Gastrointestinal: Abdominal pain and symptoms of hepatitis can be present in 3-6 percent of presenting patients
  • Neurological: Headache, confusion or altered sensorium(meningoencephalitits), loss of sensation(radiculopathies) can be present in 2-7 percent of patients
  • Cardiacvascular: Chest pain is presenting rare cardiovascular feature in brucellosis
  • Ocular: Difficulty in vision and Dimenision of vision
  • Dermatology: Rash, ulcer or tender swelling can present with brucellosis upto 10 percent of patient
Relapse
Chronic Brucellosis Presence of clinical manifestation for more then one year after established diagnosis of brucellosis is considered as chronic brucellosis.

Clincial manifestations include:

Uveitis: patients complains of difficulty of vision

Spondylitis, osteomyelitis, Arthralgias: patients complains of pain in joints or joint movement

Intermittent sweating

References

  1. Brucellosis. Wikipedia. https://en.wikipedia.org/wiki/Brucellosis. Accessed on February 4, 2016
  2. Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.
  3. Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.
  4. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.
  5. Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.
  6. Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.
  7. Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.
  8. Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.
  9. Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.
  10. Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.
  11. Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.