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Relapse occurs in 5 to 15 percent of patient usually in first 6 months following treatment, although in rare cases it may even occur in up to 12 months of treatment.<ref>Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med 2007; 4:e317.</ref><ref>Ariza J, Corredoira J, Pallares R, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995; 20:1241.</ref>
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Revision as of 16:16, 4 January 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Danitza Lukac

Overview

Symptoms of brucellosis include undulant fever, night sweats (with characteristic smell, likened to wet hay), and joint pain.[1]

Symptoms

Brucellosis
Acute brucellosis Acute brucellosis may begin with mild flu-like symptoms, or symptoms such as:[2][3][4][5][6][7][8][9][10][11]

Systemic symptoms

Depression

Focal organ wise symptoms:

  • Muscuoskeletal: Joint pain(Commonly in low back and larger joints of lower limbs)
  • Genitourinary: Pain in the genital region and increase in frequency of urination/burning senation while passing urine(2 to 20 percent of cases)
  • Pulmonary: Cough, chest pain, difficulty in breathing(pulmonary involvement present upto 7 percent of patients)
  • Gastrointestinal: Abdominal pain and symptoms of hepatitis can be present in 3-6 percent of presenting patients
  • Neurological: Headache, confusion or altered sensorium(meningoencephalitits), loss of sensation(radiculopathies) can be present in 2-7 percent of patients
  • Cardiacvascular: Chest pain is presenting rare cardiovascular feature in brucellosis
  • Ocular: Difficulty in vision and Dimenision of vision
  • Dermatology: Rash, ulcer or tender swelling can present with brucellosis upto 10 percent of patient
Relapse

Relapse occurs in 5 to 15 percent of patient usually in first 6 months following treatment, although in rare cases it may even occur in up to 12 months of treatment.[12][13]

Chronic Brucellosis Presence of clinical manifestation for more then one year after established diagnosis of brucellosis is considered as chronic brucellosis.

Clincial manifestations include:

Uveitis: patients complains of difficulty of vision

Spondylitis, osteomyelitis, Arthralgias: patients complains of pain in joints or joint movement

Intermittent sweating

References

  1. Brucellosis. Wikipedia. https://en.wikipedia.org/wiki/Brucellosis. Accessed on February 4, 2016
  2. Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.
  3. Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.
  4. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.
  5. Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.
  6. Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.
  7. Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.
  8. Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.
  9. Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.
  10. Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.
  11. Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.
  12. Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med 2007; 4:e317.
  13. Ariza J, Corredoira J, Pallares R, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995; 20:1241.