Brucellosis natural history, complications and prognosis: Difference between revisions
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The prognosis of brucellosis is good with treatment. Mortality is less then 1%, usually | The prognosis of brucellosis is good with treatment. Mortality is less then 1%, usually due to consequence of cardiac involvement or severe neurologic disease. General well-being and the body weight of the patient are useful guide to estimating the prognosis or chance of relapse.<ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017</ref> | ||
==Reference== | ==Reference== | ||
Revision as of 18:10, 9 January 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Vishal Devarkonda, M.B.B.S[3]
Overview
If left untreated, patients with brucellosis may progress to develop focal infections, relapses or chronic brucellosis.[1] Common complications of brucellosis include granulomatous hepatitis, arthritis, sacroiliitis, meningitis, orchitis, epididymitis uveitis, and endocarditis. The prognosis of brucellosis is good with adequate treatment. Relapse may occur, and symptoms may continue for years.[1][2][3]
Natural History
- Brucellosis incubation period is 2–4 weeks (range, 5 days to 5 months). If left untreated, patients with brucellosis may progress to develop focal infections, relapses or chronic brucellosis.[4]
Complications
Complications of Brucellosis include the following:[5][6][7][8][9][10][11][12][13][14]
| Complications of Brucellosis | |
|---|---|
| Osteoarticular |
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| Cardiovascular |
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| Hepatobiliary complications |
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| Genitourinary | Orchitis and epididymitis
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| Neurological |
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| Gastrointestinal | Colitis, ileitis, and spontaneous bacterial peritonitis.
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| Respiratory tract | |
| Pregnancy | Spontaneous abortion |
| Cutaneous |
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| Opthalmic | Uveitis
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Prognosis
The prognosis of brucellosis is good with treatment. Mortality is less then 1%, usually due to consequence of cardiac involvement or severe neurologic disease. General well-being and the body weight of the patient are useful guide to estimating the prognosis or chance of relapse.[15]
Reference
- ↑ 1.0 1.1 Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016
- ↑ 2.0 2.1 FAO/WHO/OIE Brucellosis in humans and animals. WHO (2006). http://www.who.int/csr/resources/publications/Brucellosis.pdf Accessed on February 3, 2016
- ↑ Brucellosis. Wikipedia. https://en.wikipedia.org/wiki/Brucellosis. Accessed on February 1, 2016
- ↑ Brucellosis. CDC. http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/brucellosis. Accessed on February 3, 2016
- ↑ Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.
- ↑ Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.
- ↑ Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.
- ↑ Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.
- ↑ Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.
- ↑ Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.
- ↑ Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.
- ↑ Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.
- ↑ Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.
- ↑ Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.
- ↑ Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017