Brucellosis diagnostic criteria: Difference between revisions
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==Overview== | ==Overview== | ||
There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on history of potential exposure, presentation consistent with the disease, | There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on history of potential exposure, presentation consistent with the disease, supporting laboratory findings.<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref><ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017</ref> | ||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on:<ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9, 2016</ref><ref>Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.</ref><ref>Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.</ref><ref>Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.</ref><ref>Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.</ref><ref>Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.</ref><ref>Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.</ref><ref>Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.</ref><ref>Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.</ref><ref>Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.</ref><ref>Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.</ref> | There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on:<ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9, 2016</ref><ref>Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.</ref><ref>Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.</ref><ref>Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.</ref><ref>Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.</ref><ref>Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.</ref><ref>Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.</ref><ref>Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.</ref><ref>Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.</ref><ref>Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.</ref><ref>Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.</ref> | ||
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|- | |- | ||
|Supporting laboratory findings | |Supporting laboratory findings | ||
| | |'''Definitive:''' | ||
*Culture and identification of [[Brucella|''Brucella spp'']]. from clinical specimens | |||
*Evidence of a fourfold or greater rise in [[Brucella|''Brucella'']] antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart | |||
'''Presumptive:''' | |||
*[[Brucella|''Brucella'']] total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or [[Brucella|''Brucella'']] microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms | |||
*Detection of [[Brucella|''Brucella'']] DNA in a clinical specimen by [[Polymerase chain reaction|PCR]] assay | |||
Other non-specific findings may include: | Other non-specific findings may include: | ||
* Complete blood count: Normal or low with relative lymphocytosis. Low platelets may be reported | * [[Complete blood count]]: Normal or low with relative lymphocytosis. Low platelets may be reported | ||
* Hemoglobin: Mild anemia is documented | * [[Hemoglobin]]: Mild anemia is documented | ||
* Normal or elevated ESR | * Normal or elevated [[ESR]] | ||
* Normal or elevated C-reactive protein levels | * Normal or elevated [[C-reactive protein]] levels | ||
* | * Normal or raised fibrinogen degraded products | ||
|} | |} | ||
==Reference== | ==Reference== | ||
Revision as of 18:52, 9 January 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Danitza Lukac
Overview
There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on history of potential exposure, presentation consistent with the disease, supporting laboratory findings.[1][2]
Diagnostic Criteria
There is no specific diagnostic criteria for Brucellosis, Diagnosis is based on:[3][4][5][6][7][8][9][10][11][12][13]
- History of potential exposure
- Presentation consistent with the disease
- Supporting laboratory findings
| Diagnosis of brucellosis | |
|---|---|
| History of potential exposure |
|
| presentation consistent with the disease | An illness characterized by acute or insidious onset of fever and one or more of the following:
|
| Supporting laboratory findings | Definitive:
Presumptive:
Other non-specific findings may include:
|
Reference
- ↑ Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016
- ↑ Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9th, 2017
- ↑ Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 9, 2016
- ↑ Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75:195.
- ↑ Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007; 25:188.
- ↑ Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325.
- ↑ Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis 2003; 7:173.
- ↑ Young EJ. Brucellosis: current epidemiology, diagnosis, and management. Curr Clin Top Infect Dis 1995; 15:115.
- ↑ Aygen B, Doganay M, Sumerkan B, et al. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Malad Infect 2002; 32:485.
- ↑ Geyik MF, Gür A, Nas K, et al. Musculoskeletal involvement of brucellosis in different age groups: a study of 195 cases. Swiss Med Wkly 2002; 132:98.
- ↑ Mousa AM, Bahar RH, Araj GF, et al. Neurological complications of brucella spondylitis. Acta Neurol Scand 1990; 81:16.
- ↑ Pappas G, Bosilkovski M, Akritidis N, et al. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37:e95.
- ↑ Herrick JA, Lederman RJ, Sullivan B, et al. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis 2014; 14:520.