Bacterial meningitis pathophysiology: Difference between revisions
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*Once colonized, the invasion of bacteria occurs via special adhesion proteins called adhesins.<ref name="pmid1901998">{{cite journal| author=Stephens DS, Farley MM| title=Pathogenic events during infection of the human nasopharynx with Neisseria meningitidis and Haemophilus influenzae. | journal=Rev Infect Dis | year= 1991 | volume= 13 | issue= 1 | pages= 22-33 | pmid=1901998 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1901998 }} </ref> | *Once colonized, the invasion of bacteria occurs via special adhesion proteins called adhesins.<ref name="pmid1901998">{{cite journal| author=Stephens DS, Farley MM| title=Pathogenic events during infection of the human nasopharynx with Neisseria meningitidis and Haemophilus influenzae. | journal=Rev Infect Dis | year= 1991 | volume= 13 | issue= 1 | pages= 22-33 | pmid=1901998 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1901998 }} </ref> | ||
*Adhesins may help bacteria to cross epithelial barrier intracellularly or intercellularly. | *Adhesins may help bacteria to cross epithelial barrier intracellularly or intercellularly. | ||
*Bacteria seeds transcellularly to enter the intravascular space. | |||
*Surface encapsulation may play important role in entry of bacterial pathogen across epithelium into blood stream | |||
===Meningeal infalmmation=== | ===Meningeal infalmmation=== | ||
Revision as of 19:19, 10 January 2017
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Bacterial meningitis Microchapters |
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Diagnosis |
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Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
Overview
Pathophysiology
Pathogenensis of bacterial meningitis is a complex process which may occur due to imbalance between the host immune response and virulence factors of pathogen causing infection. Following steps may explain the underlying process in a comprehensive way:
Transmission
- H. influenza type b and N. meningitides may be transmitted by close contact or prolong contact with patient suffering from meningitis[1]
- It may also spread by exchanging throat and respiratory secretions (couging and kissing)
- Listeria monocytogenes may spread by eating contaminated food.
- Most people are carriers and do not develop the disease.
Colonization and evasion of host immune response
- Colonization of pathogenic organism involves evasion of host immune response mechanism.
- IgA protease produced by bacterial pathogen cleave mucosal IgA antibodies which prevent the bacteria from attachment to the mucosal surface. [2]
- Once host immune response is evaded, bacteria attach themselves to the mucosa via fimbriae or pilli which facilitate colonization process.
Invasion and seeding
- Once colonized, the invasion of bacteria occurs via special adhesion proteins called adhesins.[2]
- Adhesins may help bacteria to cross epithelial barrier intracellularly or intercellularly.
- Bacteria seeds transcellularly to enter the intravascular space.
- Surface encapsulation may play important role in entry of bacterial pathogen across epithelium into blood stream
Meningeal infalmmation
Associated conditons
Role of Genetics
Gross pathology
Microscopic pathology
References
- ↑ https://www.cdc.gov/meningitis/bacterial.html Accessed on 10th Jan, 2017
- ↑ 2.0 2.1 Stephens DS, Farley MM (1991). "Pathogenic events during infection of the human nasopharynx with Neisseria meningitidis and Haemophilus influenzae". Rev Infect Dis. 13 (1): 22–33. PMID 1901998.