Helicobacter pylori infection diagnostic test

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]

Nonendoscpic diagnostic studies

Antibody testing is inexpensive and widely available but poor PPV in populations with a low prevalence of H. pylori infection limits its usefulness in clinical practice.

The UBTs and fecal antigen tests provide reliable means of identifying active H. pylori infection before antibiotic therapy.

The UBT is the most reliable nonendoscopic test to document eradication of H. pylori infection.

The monclonal fecal antigen test provides another nonendoscopic means of establishing H. pylori cure after antibiotic treatment.

Testing to prove H. pylori eradication appears to be most accurate if performed at least 4 wk after the completion of antibiotic therapy.

The nonendoscopic diagnostic testing methods for H.pylori include:

• Antibody tests
• Urea breath test
• Fecal antigen test

Antibody tests

• Antibody testing depends on the detection of H.pylori specific IgG antibodies in serum, whole blood, or urine.
• The IgG antibodies typically become detected 21 days after infection and can remain present long after eradication.
• Antibodies are detected using