Tropical sprue pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Bacterial overgrowth leading to toxin production.<ref name="Walker2003">{{cite journal|last1=Walker|first1=Marjorie M|title=What is tropical sprue?|journal=Journal of Gastroenterology and Hepatology|volume=18|issue=8|year=2003|pages=887–890|issn=0815-9319|doi=10.1046/j.1440-1746.2003.03127.x}}</ref> | |||
==Histology== | ==Histology== | ||
The histological changes of TS include: Flattening of the villi and small intestinal inflammation which are similar to an [[autoimmune disorder]] Coeliac disease (also known as ''[[coeliac sprue]]''). | The histological changes of TS include: Flattening of the villi and small intestinal inflammation which are similar to an [[autoimmune disorder]] Coeliac disease (also known as ''[[coeliac sprue]]''). | ||
Revision as of 19:45, 15 February 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Pathophysiology
Bacterial overgrowth leading to toxin production.[1]
Histology
The histological changes of TS include: Flattening of the villi and small intestinal inflammation which are similar to an autoimmune disorder Coeliac disease (also known as coeliac sprue).
| Diagnosis | Villous morphology | Findings in Lamina propria | Involved portion of the GI tract |
|---|---|---|---|
| Tropical sprue | Mild to moderate blunting of the villi with an increased number of Intraepithelial lymphocytes. | Increased number of plasma cells and eosinophils. | Ileum > Duodenum > Colon |
| Celiac sprue | Variable, often there is a complete flattening of the villi. Always there is an increased number of Intraepithelial lymphocytes | Plasma cells > Eosinophils > Neutrophils. | Duodenum > Ileum. |
References
- ↑ Walker, Marjorie M (2003). "What is tropical sprue?". Journal of Gastroenterology and Hepatology. 18 (8): 887–890. doi:10.1046/j.1440-1746.2003.03127.x. ISSN 0815-9319.