Tropical sprue pathophysiology: Difference between revisions
Jump to navigation
Jump to search
| Line 8: | Line 8: | ||
==Pathophysiology== | ==Pathophysiology== | ||
'''Infection''' | |||
* Accompanied by Fever at the onset of the disease | |||
* Increase in the gram-negative bacterial toxins and bacterial colony counts | |||
* Precipitated by a history of acute gastroenteritis.<ref name="pmid26115751">{{cite journal| author=McCarroll MG, Riddle MS, Gutierrez RL, Porter CK| title=Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study. | journal=Dig Dis Sci | year= 2015 | volume= 60 | issue= 11 | pages= 3379-85 | pmid=26115751 | doi=10.1007/s10620-015-3768-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26115751 }} </ref> | |||
* There is an increase in the inflammatory cells in the lamina propria with variable edema | |||
* Good clinical response to Tetracycline with restoration of the normal histology. | |||
Bacterial overgrowth leading to toxin production.<ref name="Walker2003">{{cite journal|last1=Walker|first1=Marjorie M|title=What is tropical sprue?|journal=Journal of Gastroenterology and Hepatology|volume=18|issue=8|year=2003|pages=887–890|issn=0815-9319|doi=10.1046/j.1440-1746.2003.03127.x}}</ref> | Bacterial overgrowth leading to toxin production.<ref name="Walker2003">{{cite journal|last1=Walker|first1=Marjorie M|title=What is tropical sprue?|journal=Journal of Gastroenterology and Hepatology|volume=18|issue=8|year=2003|pages=887–890|issn=0815-9319|doi=10.1046/j.1440-1746.2003.03127.x}}</ref> | ||
Revision as of 13:55, 17 February 2017
|
Tropical sprue Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Tropical sprue pathophysiology On the Web |
|
American Roentgen Ray Society Images of Tropical sprue pathophysiology |
|
Risk calculators and risk factors for Tropical sprue pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Overview
Pathophysiology
Infection
- Accompanied by Fever at the onset of the disease
- Increase in the gram-negative bacterial toxins and bacterial colony counts
- Precipitated by a history of acute gastroenteritis.[1]
- There is an increase in the inflammatory cells in the lamina propria with variable edema
- Good clinical response to Tetracycline with restoration of the normal histology.
Bacterial overgrowth leading to toxin production.[2]
Histology
The histological changes of TS include: Flattening of the villi and small intestinal inflammation which are similar to an autoimmune disorder Coeliac disease (also known as coeliac sprue).
| Diagnosis | Villous morphology | Findings in Lamina propria | Involved portion of the GI tract |
|---|---|---|---|
| Tropical sprue | Mild to moderate blunting of the villi with an increased number of Intraepithelial lymphocytes. | Increased number of plasma cells and eosinophils. | Ileum > Duodenum > Colon |
| Celiac sprue | Variable, often there is a complete flattening of the villi. Always there is an increased number of Intraepithelial lymphocytes | Plasma cells > Eosinophils > Neutrophils. | Duodenum > Ileum. |
References
- ↑ McCarroll MG, Riddle MS, Gutierrez RL, Porter CK (2015). "Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study". Dig Dis Sci. 60 (11): 3379–85. doi:10.1007/s10620-015-3768-8. PMID 26115751.
- ↑ Walker, Marjorie M (2003). "What is tropical sprue?". Journal of Gastroenterology and Hepatology. 18 (8): 887–890. doi:10.1046/j.1440-1746.2003.03127.x. ISSN 0815-9319.