Brucellosis differential diagnosis: Difference between revisions
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{{Brucellosis}} | {{Brucellosis}} | ||
{{CMG}} {{AE}}{{DL}} {{VD}} | {{CMG}} {{AE}}{{DL}} {{VD}} | ||
== Overview == | ==Overview== | ||
[[Brucellosis]] must be differentiated from [[Typhoid fever]], [[Malaria]], [[Tuberculosis]], [[Lymphoma]], [[Dengue fever|Dengue]], [[Leptospirosis]], [[Rheumatology|Rheumatic disease]], [[Epstein-barr virus]], [[Toxoplasmosis]], [[Cytomegalovirus]], and [[Human Immunodeficiency Virus|HIV]]. | [[Brucellosis]] must be differentiated from [[Typhoid fever]], [[Malaria]], [[Tuberculosis]], [[Lymphoma]], [[Dengue fever|Dengue]], [[Leptospirosis]], [[Rheumatology|Rheumatic disease]], [[Epstein-barr virus]], [[Toxoplasmosis]], [[Cytomegalovirus]], and [[Human Immunodeficiency Virus|HIV]]. | ||
==Differentiating Brucellosis from other Diseases== | |||
== Differentiating Brucellosis from other Diseases == | [[Brucellosis]] must be differentiated from [[Typhoid fever]], [[Malaria]], [[Tuberculosis]], Lymphoma, [[Dengue]], [[Leptospirosis]], [[Rheumatic disease]], [[Epstein Barr virus|Epstein-barr virus]], [[Toxoplasmosis]], [[Cytomegalovirus causes|Cytomegalovirus]], and [[Human Immunodeficiency Virus|HIV]].<ref name="pmid1593042322">{{cite journal|author=Pappas G, Akritidis N, Bosilkovski M, Tsianos E|title=Brucellosis.|journal=N Engl J Med|year=2005|volume=352|issue=22|pages=2325-36|pmid=15930423|doi=10.1056/NEJMra050570|pmc=|url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15930423}}</ref><ref>Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on January,2017</ref><ref name="pmid754636422">{{cite journal|year=1995|title=Brucellosis: current epidemiology, diagnosis, and management.|url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7546364|journal=Curr Clin Top Infect Dis|volume=15|issue=|pages=115-28|doi=|pmc=|pmid=7546364|author=Young EJ}}</ref><ref name="enf22">Enfermedades infecciosas: Brucelosis -Diagnóstico de Brucelosis,Guia para el Equipo de Salud. Ministerio de Salud-Argentina. http://www.msal.gob.ar/images/stories/bes/graficos/0000000304cnt-guia-medica-brucelosis.pdf. Accessed on February 2, 2016</ref> | ||
[[Brucellosis]] must be differentiated from [[Typhoid fever]], [[Malaria]], [[Tuberculosis]], Lymphoma, [[Dengue]], [[Leptospirosis]], [[Rheumatic disease]], [[Epstein Barr virus|Epstein-barr virus]], [[Toxoplasmosis]], [[Cytomegalovirus causes|Cytomegalovirus]], and [[Human Immunodeficiency Virus|HIV]].<ref name=" | |||
A detailed clinical history which includes recent travel history, recent camping or hunting, consumption of unpasteurized milk or raw meat products, and occupational history should be obtained, in order to differentiate [[Brucellosis]] from other diseases. | A detailed clinical history which includes recent travel history, recent camping or hunting, consumption of unpasteurized milk or raw meat products, and occupational history should be obtained, in order to differentiate [[Brucellosis]] from other diseases. | ||
{| class="wikitable" | {| class="wikitable" | ||
!Differentiating diagnosis of Brucellosis | !Differentiating diagnosis of Brucellosis | ||
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|[[Brucellosis]] | |[[Brucellosis]] | ||
|✔ | |✔ | ||
| | |✔ | ||
|✘ | |||
|✔ | |||
|✘ | |✘ | ||
|✔ | |✔ | ||
|✔ | |✔ | ||
|✔ | |✔ | ||
| | |[[Lymphocytosis|Relative lymphocytosis]] | ||
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|✘ | |✘ | ||
|✔ | |✔ | ||
| | |✘ | ||
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|✔ | |||
|✔ | |✔ | ||
| | |Decreased [[hemoglobin]] | ||
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|✔ | |✔ | ||
|✘ | |✘ | ||
| | |✘ | ||
|✔ | |||
|✔ | |✔ | ||
| | |Microcytosis, | ||
Elevated [[LDH]] | |||
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|✔ | |✔ | ||
|✔ | |✔ | ||
| | |✔ | ||
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| | |Mild normocytic [[anemia]], [[hyponatremia]], and | ||
[[hypercalcemia]] | |||
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|✔ | |✔ | ||
|✔ | |✔ | ||
| | |✘ | ||
| | |✔ | ||
| | |✘ | ||
| | |Increase [[ESR]], Increased [[LDH]] | ||
| | | | ||
| | | | ||
|- | |- | ||
|Mumps | |[[Mumps]] | ||
|✔ | |✔ | ||
|✘ | |✘ | ||
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|✘ | |✘ | ||
|✘ | |✘ | ||
| | |✔ | ||
| | |✘ | ||
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| | |[[Lymphocytosis|Relative lymphocytosis]], serum [[amylase]] elevated | ||
| | | | ||
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|- | |- | ||
|Rheumatoid arthritis | |[[Rheumatoid arthritis]] | ||
|✘ | |✘ | ||
|✔ | |✔ | ||
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|✘ | |✘ | ||
|✘ | |✘ | ||
| | |✘ | ||
| | |✘ | ||
|✔ | |✔ | ||
| | |[[ESR]] and [[CRP]] elevated , positive [[rheumatoid factor]] | ||
| | | | ||
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|- | |- | ||
|SLE | |[[SLE]] | ||
|✘ | |✘ | ||
|✔ | |✔ | ||
|✘ | |✘ | ||
|✔ | |✔ | ||
|✔ | |✔ | ||
| | |✘ | ||
|✘ | |||
|✔ | |||
|[[ESR]] and [[CRP]] elevated, positive [[ANA]] | |||
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|✘ | |✘ | ||
|✘ | |✘ | ||
|✔ | |✔ | ||
| | |✔ | ||
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| | |✘ | ||
|✔ | |||
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|} | |} | ||
==Reference== | ==Reference== | ||
{{reflist|2}} | {{reflist|2}}<references /> | ||
[[Category:Bacterial diseases]] | [[Category:Bacterial diseases]] | ||
[[Category:Occupational diseases]] | [[Category:Occupational diseases]] | ||
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[[Category:Biological weapons]] | [[Category:Biological weapons]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Revision as of 16:14, 22 February 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Danitza Lukac Vishal Devarkonda, M.B.B.S[2]
Overview
Brucellosis must be differentiated from Typhoid fever, Malaria, Tuberculosis, Lymphoma, Dengue, Leptospirosis, Rheumatic disease, Epstein-barr virus, Toxoplasmosis, Cytomegalovirus, and HIV.
Differentiating Brucellosis from other Diseases
Brucellosis must be differentiated from Typhoid fever, Malaria, Tuberculosis, Lymphoma, Dengue, Leptospirosis, Rheumatic disease, Epstein-barr virus, Toxoplasmosis, Cytomegalovirus, and HIV.[1][2][3][4]
A detailed clinical history which includes recent travel history, recent camping or hunting, consumption of unpasteurized milk or raw meat products, and occupational history should be obtained, in order to differentiate Brucellosis from other diseases.
| Differentiating diagnosis of Brucellosis | Symptoms | Signs | Diagnosis | Additional Findings | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fever | Rash | Diarrhea | Abdominal pain | Weight loss | Painful lymphadenopathy | Hepatosplenomegaly | Arthritis | Lab Findings | Imaging Findings | ||
| Brucellosis | ✔ | ✔ | ✘ | ✔ | ✘ | ✔ | ✔ | ✔ | Relative lymphocytosis | ||
| Typhoid fever | ✔ | ✔ | ✘ | ✔ | ✘ | ✘ | ✔ | ✔ | Decreased hemoglobin | ||
| Malaria | ✔ | ✘ | ✔ | ✔ | ✘ | ✘ | ✔ | ✔ | Microcytosis,
Elevated LDH |
||
| Tuberculosis | ✔ | ✔ | ✘ | ✔ | ✔ | ✔ | ✔ | ✔ | Mild normocytic anemia, hyponatremia, and | ||
| Lymphoma | ✔ | ✘ | ✘ | ✔ | ✔ | ✘ | ✔ | ✘ | Increase ESR, Increased LDH | ||
| Mumps | ✔ | ✘ | ✘ | ✘ | ✘ | ✔ | ✘ | ✘ | Relative lymphocytosis, serum amylase elevated | ||
| Rheumatoid arthritis | ✘ | ✔ | ✘ | ✘ | ✘ | ✘ | ✘ | ✔ | ESR and CRP elevated , positive rheumatoid factor | ||
| SLE | ✘ | ✔ | ✘ | ✔ | ✔ | ✘ | ✘ | ✔ | ESR and CRP elevated, positive ANA | ||
| HIV | ✘ | ✘ | ✘ | ✔ | ✔ | ✔ | ✘ | ✔ | |||
Reference
- ↑ Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005). "Brucellosis". N Engl J Med. 352 (22): 2325–36. doi:10.1056/NEJMra050570. PMID 15930423.
- ↑ Brucellosis "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on January,2017
- ↑ Young EJ (1995). "Brucellosis: current epidemiology, diagnosis, and management". Curr Clin Top Infect Dis. 15: 115–28. PMID 7546364.
- ↑ Enfermedades infecciosas: Brucelosis -Diagnóstico de Brucelosis,Guia para el Equipo de Salud. Ministerio de Salud-Argentina. http://www.msal.gob.ar/images/stories/bes/graficos/0000000304cnt-guia-medica-brucelosis.pdf. Accessed on February 2, 2016