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| ==Overview== | | ==Overview== |
| TS bears all the hallmarks of an infectious disease although the exact etiology remains largely unknown despite numerous efforts to identify the etiological agent.
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| ==Causes== | | ==Causes== |
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| The cause of tropical sprue is not known. It has been suggested that it is caused by bacterial, viral, amoebal, or parasitic infection which affects residents of (or visitors to) the tropics. The resolution of symptoms after long-term antibiotic treatment with tetracycline or sulphamethoxazole/trimethoprim combined with vitamin supplementation suggests an infectious cause even though a causative micro-organism has never been demonstrated.<ref name="Walker2003">{{cite journal|last1=Walker|first1=Marjorie M|title=What is tropical sprue?|journal=Journal of Gastroenterology and Hepatology|volume=18|issue=8|year=2003|pages=887–890|issn=0815-9319|doi=10.1046/j.1440-1746.2003.03127.x}}</ref><ref name="Cook1984">{{cite journal|last1=Cook|first1=G.C.|title=AETIOLOGY AND PATHOGENESIS OF POSTINFECTIVE TROPICAL MALABSORPTION (TROPICAL SPRUE)|journal=The Lancet|volume=323|issue=8379|year=1984|pages=721–723|issn=01406736|doi=10.1016/S0140-6736(84)92231-1}}</ref>
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| * The bacteria most commonly isolated include:<br>
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| ** Klebsiella pneumoniae
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| ** Escherichia coli
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| ** Enterobacter cloacae.
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| * Less commonly identified bacteria include:<br>
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| ** Alcaligenes faecalis
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| ** Enterobacter aerogenes
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| ** Hafnia spp.<ref name="Cook1984">{{cite journal|last1=Cook|first1=G.C.|title=AETIOLOGY AND PATHOGENESIS OF POSTINFECTIVE TROPICAL MALABSORPTION (TROPICAL SPRUE)|journal=The Lancet|volume=323|issue=8379|year=1984|pages=721–723|issn=01406736|doi=10.1016/S0140-6736(84)92231-1}}</ref>
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| ==References== | | ==References== |