Sandbox: Breast Abscess: Difference between revisions
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==Historic Perspective== | ==Historic Perspective== | ||
==Classification== | ==Classification== | ||
Breast Abscess may be classified according to | Breast Abscess may be classified according to anatomical location, clinical presentation and lactation state of the patient into subtypes.<ref name="pmid7755694">{{cite journal| author=Dixon JM| title=ABC of breast diseases. Breast infection. | journal=BMJ | year= 1994 | volume= 309 | issue= 6959 | pages= 946-9 | pmid=7755694 | doi= | pmc=2541130 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7755694 }} </ref> | ||
* | *Anatomical location: subcutaneous, subareolar, interlobular, central and retromammary. | ||
*Lactation state: Lactational and Non-Lactational. | *Lactation state: Lactational and Non-Lactational. | ||
*Clinical presentation: primary and secondary. | *Clinical presentation: primary and secondary. | ||
Revision as of 15:04, 23 February 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Synonyms and keywords: Mammary abscess
Overview
Historic Perspective
Classification
Breast Abscess may be classified according to anatomical location, clinical presentation and lactation state of the patient into subtypes.[1]
- Anatomical location: subcutaneous, subareolar, interlobular, central and retromammary.
- Lactation state: Lactational and Non-Lactational.
- Clinical presentation: primary and secondary.
Pathophysiology
Following untreated Mastitis, breast abscess could occur. Breast abscess is usually caused by staph aureus bacterial infection to an injured breast skin. The bacteria produces killing substances that necrotize the tissue. In a reaction to these bacterial substances, assembled white blood cells in this tissue produces anti-bacterial bodies that help in killing the bacteria. However, these cells cause damage to the tissue forming abscess as well. As the breast abscess is the complicated form of mastitis, the pathophysiology is mostly like the mastitis pathophysiology.[2]
Pathogenesis
Breast abscess pathogenesis depends on the lactation condition of the woman.
- Lactational:
- Injured breast skin allows the entrance of the bacteria to the mammillary ducts. This bacteria can be from the infant or the mother herself. Overproduction of the breast milk with no flow to the infant forms a good field for the bacteria to cause infection.[3]
- Breast Duct Ectasia: Metaplastic change of the duct cells can cause duct ectasia. This change causes widening of the ducts lining which leads to thickening of the ducts and obstruction. The ducts become filled with fluid which leads to nipple discharge and infection by the entrance of the bacteria and can form pus and abscess as a final result. [4]
- Non-Lactional:
Non lactational breast abscess is less common than lactational form.
Gross Pathology
Microscopic Pathology
Causes
Breast abscess is a bacterial infectious disease that is caused by many bacterial pathogens. It is almost caused by the same pathogens causing mastitis. To understand the common species causing breast abscess we can classify them into gram +ve and gram -ve bacteria. [5]
| Bacterial pathogens causing breast abscess | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gram +ve | Gram -ve | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Staphylococcus Aureus (Most common cause of the lactational abscess) •MRSA •Coagulase -ve Staphylococcus Aureus | Streptococcus pyogens | Lactobacillus | Clostridium | Veillonella | Bacteroids | Escherishia Coli | Enterobacteria | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ Dixon JM (1994). "ABC of breast diseases. Breast infection". BMJ. 309 (6959): 946–9. PMC 2541130. PMID 7755694.
- ↑ Kobayashi SD, Malachowa N, DeLeo FR (2015). "Pathogenesis of Staphylococcus aureus abscesses". Am J Pathol. 185 (6): 1518–27. doi:10.1016/j.ajpath.2014.11.030. PMC 4450319. PMID 25749135.
- ↑ Marchant DJ (2002). "Inflammation of the breast". Obstet Gynecol Clin North Am. 29 (1): 89–102. PMID 11892876.
- ↑ Bundred NJ, Dixon JM, Lumsden AB, Radford D, Hood J, Miles RS; et al. (1985). "Are the lesions of duct ectasia sterile?". Br J Surg. 72 (10): 844–5. PMID 4041720.
- ↑ Dabbas N, Chand M, Pallett A, Royle GT, Sainsbury R (2010). "Have the organisms that cause breast abscess changed with time?--Implications for appropriate antibiotic usage in primary and secondary care". Breast J. 16 (4): 412–5. doi:10.1111/j.1524-4741.2010.00923.x. PMID 20443790.