Staphylococcus aureus infection pathophysiology

Staphylococcus aureus infection Main page
Overview
Classification
Pathophysiology
Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]

Pathophysiology

Staphylococcus aureus is a highly virulent bacteria that has been recognized as a cause of a wide variety of diseases in humans. Approximately 60% of humans are colonized with Staphylococcus aureus (the nasal membranes and skin are the common habitat). Several strains of Staphylococcus aureus bacteria exist. The characteristic attribute of a particular strain such as toxins and extracellular factors, invasive properties (such as adherence, biofilm formation, and resistance to phagocytosis), as well as the immune defense mechanisms of the host, majorly determine the pathogenesis of Staphylococcus aureus infection. Staphylococcus aureus causes several infections ranging from mild infections to invasive diseases that are life threatening. Infections caused by Staphylococcus aureus include skin and soft tissue infections, osteomyelitis, food poisoning, pneumonia, infective endocarditis and sepsis. Some of the virulence factors that have been recognized in the pathogenesis of Staphylococcus aureus infections include:

• Staphylococcal superantigens (SAgs)

1. These have been strongly implicated in a wide range of illnesses such as toxic shock syndrome and staphylococcal food poisoning.
2. Several studies also suggest staphylococcal superantigens play a role in diseases such as atopic dermatitis, some forms of psoriasis, Kawasaki disease, and chronic rhinosinusitis.
3. Staphylococcal superantigens are exotoxins with more than 20 distinct types, and most staphylococcus aureus strains encode many superantigen gene. Staphylococcus superantigens include staphylococcal enterotoxins, staphylococcal enterotoxin-like proteins, and toxic shock syndrome toxin-1.
4. Staphylococcal enterotoxins cause food poisoning via ingestion of contaminated food. These enterotoxins have a very high stability and they are not easily denatured by heat and low pH (mild cooking or food digestion in the stomach cannot easily eradicate these toxins).
5. Unlike most conventional peptides that stimulate roughly 1% of naive T-cells, a staphylococcal superantigen can simultaneously activate a large proportion of T lymphocytes (up to 20%).
6. Staphylococcal superantigens are distinct because of their ability to bypass highly specific antigen-driven interaction between T-cells and antigen presenting cells.
7. The superantigens can uniquely activate T lymphocytes by directly crosslinking certain TCR Vβ (T cell receptor β-chain variable domain).
8. Numerous superantigen-activated T cells can then release several proinflammatory cytokines (this can lead to a “cytokine storm” phenomenon in severe cases, as seen in toxic shock syndrome). Superantigens also activate antigen presenting cells and this contributes to cytokine release.

• Alpha-hemolysin (α-toxin)

1. This has been implicated in skin and soft tissue infections, and invasive Staphylococcus aureus diseases.
2. It is a pore-forming cytotoxin, it forms transmembrane pores on the surface of target cells.
3. Imbalance in ion homeostasis occur as a result of the pore formation (efflux of potassium cations and ATP or influx of calcium ions). This eventually result in cell death. Alpha-toxin targets a variety of cell types including epithelial and endothelial cells, platelets and blood cells.