Tetanus differential diagnosis: Difference between revisions
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{| style="border: 2px solid #DCDCDC; font-size: 90%; width: 83%;" | {| style="border: 2px solid #DCDCDC; font-size: 90%; width: 83%;" | ||
|+ '''Differential Diagnosis | |+ '''Differential Diagnosis of Tetanus''' | ||
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease | ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease | ||
! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis | ! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis | ||
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! align="center" style="background:#4479BA; color: #FFFFFF;" |Laboratory Findings | ! align="center" style="background:#4479BA; color: #FFFFFF;" |Laboratory Findings | ||
|- | |- | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Tetanus]] | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Tetanus]] | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
*Tonic contraction of muscles between the spasmodic episodes | *Tonic contraction of muscles between the spasmodic episodes | ||
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* Human TIG | * Human TIG | ||
|- | |- | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Neuroleptic malignant syndrome|Neuroleptic Malignant Syndrome]] | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Neuroleptic malignant syndrome|Neuroleptic Malignant Syndrome]] | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
*History of intake of offending drugs e.g [[neuroleptics]] like: | *History of intake of offending drugs e.g [[neuroleptics]] like: | ||
**[[Fluphenazine]] | **[[Fluphenazine]] | ||
**[[Haloperidol]] | **[[Haloperidol]] | ||
**[[Risperidone]] | **[[Risperidone]] | ||
*[[Autonomic instability]] | *[[Autonomic instability]] | ||
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* [[Agitation]] | * [[Agitation]] | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
* [[Myoglobinemia]] | |||
* Elevated [[LDH]] | |||
* Elevated [[creatine kinase]] | |||
* [[Hyperkalemia]] | |||
* Elevated [[AST]] and [[ALT]] | |||
* [[Hyperphosphatemia]] | |||
* Elevated [[alkaline phosphatase]] | |||
* [[Hyperuricemia]] | |||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
* Supportive therapy | * Supportive therapy | ||
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** [[Bromocriptine]] | ** [[Bromocriptine]] | ||
|- | |- | ||
| style="background: #F5F5F5; padding: 5px;" | [[Meningitis|Viral Meningitis]]<ref name="pmid24326618">{{cite journal| author=Chow E, Troy SB| title=The differential diagnosis of hypoglycorrhachia in adult patients. | journal=Am J Med Sci | year= 2014 | volume= 348 | issue= 3 | pages= 186-90 | pmid=24326618 | doi=10.1097/MAJ.0000000000000217 | pmc=4065645 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24326618 }} </ref><ref name="pmid22880096">{{cite journal| author=Leen WG, Willemsen MA, Wevers RA, Verbeek MM| title=Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice. | journal=PLoS One | year= 2012 | volume= 7 | issue= 8 | pages= e42745 | pmid=22880096 | doi=10.1371/journal.pone.0042745 | pmc=3412827 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22880096 | | style="background: #F5F5F5; padding: 5px;" | [[Meningitis|Viral Meningitis]]<ref name="pmid24326618">{{cite journal| author=Chow E, Troy SB| title=The differential diagnosis of hypoglycorrhachia in adult patients. | journal=Am J Med Sci | year= 2014 | volume= 348 | issue= 3 | pages= 186-90 | pmid=24326618 | doi=10.1097/MAJ.0000000000000217 | pmc=4065645 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24326618 }} </ref><ref name="pmid22880096">{{cite journal| author=Leen WG, Willemsen MA, Wevers RA, Verbeek MM| title=Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice. | journal=PLoS One | year= 2012 | volume= 7 | issue= 8 | pages= e42745 | pmid=22880096 | doi=10.1371/journal.pone.0042745 | pmc=3412827 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22880096 }} </ref> | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
* [[Fever]] | * [[Fever]] | ||
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** [[Acetaminophen]] for [[fever]]. | ** [[Acetaminophen]] for [[fever]]. | ||
* Anti-viral therapy: | * Anti-viral therapy: | ||
** [[Acyclovir]] | ** [[Acyclovir]] <sup>[[Viral meningitis medical therapy#cite note-pmid15319091-2|[2]]]</sup> | ||
** [[Pleconaril]] | ** [[Pleconaril]] | ||
|- | |- | ||
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* [[Prednisone]], [[plasmapheresis]], [[IVIG]] ( some success) | * [[Prednisone]], [[plasmapheresis]], [[IVIG]] ( some success) | ||
|- | |- | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Drug]] induced [[Tardive dyskinesia|(Tardive dyskinesia]]) | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Drug]] induced [[Tardive dyskinesia|(Tardive dyskinesia]]) | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
*History of intake of the offending drug for at least one month | *History of intake of the offending drug for at least one month | ||
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**''Strychnos nux vomica seeds'' | **''Strychnos nux vomica seeds'' | ||
**Rodenticide | **Rodenticide | ||
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* Blood assay | * Blood assay | ||
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* Urine assay | * Urine assay | ||
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|- | |- | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Hypocalcaemia]] | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Hypocalcaemia]] | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | | |||
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|- | |- | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Dental abscess]] | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Dental abscess]] | ||
| style="background: #DCDCDC; padding: 5px;" | | | style="background: #DCDCDC; padding: 5px;" | | ||
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|- | |- | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Parkinson's disease]] | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Parkinson's disease]] | ||
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|} | |} | ||
Revision as of 21:13, 12 June 2017
Tetanus Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Tetanus differential diagnosis On the Web |
American Roentgen Ray Society Images of Tetanus differential diagnosis |
Risk calculators and risk factors for Tetanus differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Michael Maddaleni, B.S.; Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2]
Overview
Tetanus must be differentiated from strychnine poisoning, dental infections, drug reactions, hypocalcemia, meningitis, stroke and stiff man syndrome.[1]
Differentiating Tetanus from other Diseases
Some of the other diseases that need to be considered when trying to diagnose tetanus include:[2][3][4]
- Dental abscess
- Drug reactions
- Hypocalcaemia
- Meningitis
- Stiff man syndrome
- Strychnine poisoning
- Parkinson's disease
Differential for Unilateral Involuntary Face Movements
The differential diagnosis for abnormal one sided movements of the face includes:[5][6][7][8][9][10][11][12][13][14][15]
- Tetanus associated trismus
- Temporomandibular joint (TMJ) dysfunction
- Tetany
- Unilateral jaw dystonia
- Exclusive facial myokymia
- Exclusive hemifacial spasm
- Multiple sclerosis (MS) associated tonic spasms
- Focal motor epilepsy
- Hemimasticatory spasm in the presence or absence hemiatrophy of the face
Disease | Diagnosis | Treatment | ||
---|---|---|---|---|
Symptoms | Signs | Laboratory Findings | ||
Tetanus |
|
|
|
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Neuroleptic Malignant Syndrome |
|
|
| |
Viral Meningitis[16][17] |
|
|
|
|
Stiff man syndrome |
|
|
|
|
Drug induced (Tardive dyskinesia) |
|
|
|
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Strychnine poisoning[18][19][20][21] |
|
|
||
Hypocalcaemia | ||||
Dental abscess | ||||
Parkinson's disease |
References
- ↑ Anisha Doshi, Clare Warrell, Dima Dahdaleh & Dimitri Kullmann (2014). "Just a graze? Cephalic tetanus presenting as a stroke mimic". Practical neurology. 14 (1): 39–41. doi:10.1136/practneurol-2013-000541. PMID 24052566. Unknown parameter
|month=
ignored (help) - ↑ E. Andreadou, E. Kattoulas, C. Sfagos & D. Vassilopoulos (2007). "Stiff person syndrome: avoiding misdiagnosis". Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 28 (1): 35–37. doi:10.1007/s10072-007-0745-9. PMID 17385093. Unknown parameter
|month=
ignored (help) - ↑ Lisa Mitchell, William Adams & Francois Aspesberro (2017). "Case 6: Episodic Stiffness in a 30-month-old Girl". Pediatrics in review. 38 (1): 52–53. doi:10.1542/pir.2014-0142. PMID 28044038. Unknown parameter
|month=
ignored (help) - ↑ P. D. Thompson, J. A. Obeso, G. Delgado, J. Gallego & C. D. Marsden (1986). "Focal dystonia of the jaw and the differential diagnosis of unilateral jaw and masticatory spasm". Journal of neurology, neurosurgery, and psychiatry. 49 (6): 651–656. PMID 3734821. Unknown parameter
|month=
ignored (help) - ↑ P. D. Thompson, J. A. Obeso, G. Delgado, J. Gallego & C. D. Marsden (1986). "Focal dystonia of the jaw and the differential diagnosis of unilateral jaw and masticatory spasm". Journal of neurology, neurosurgery, and psychiatry. 49 (6): 651–656. PMID 3734821. Unknown parameter
|month=
ignored (help) - ↑ J. R. Berger, W. A. Sheremata & E. Melamed (1984). "Paroxysmal dystonia as the initial manifestation of multiple sclerosis". Archives of neurology. 41 (7): 747–750. PMID 6743065. Unknown parameter
|month=
ignored (help) - ↑ W. B. Matthews (1975). "Paroxysmal symptoms in multiple sclerosis". Journal of neurology, neurosurgery, and psychiatry. 38 (6): 617–623. PMID 1151430. Unknown parameter
|month=
ignored (help) - ↑ P. D. Thompson & W. M. Carroll (1983). "Hemimasticatory spasm--a peripheral paroxysmal cranial neuropathy?". Journal of neurology, neurosurgery, and psychiatry. 46 (3): 274–276. PMID 6842234. Unknown parameter
|month=
ignored (help) - ↑ P. D. Thompson & W. M. Carroll (1983). "Hemimasticatory and hemifacial spasm: a common pathophysiology?". Clinical and experimental neurology. 19: 110–119. PMID 6568919.
- ↑ L. R. Jenkyn, D. B. Walsh, C. M. Culver & A. G. Reeves (1977). "Clinical signs in diffuse cerebral dysfunction". Journal of neurology, neurosurgery, and psychiatry. 40 (10): 956–966. PMID 591973. Unknown parameter
|month=
ignored (help) - ↑ J. D. Rugh & W. K. Solberg (1976). "Psychological implications in temporomandibular pain and dysfunction". Oral sciences reviews. 7: 3–30. PMID 775369.
- ↑ Bond WS (1984). "Detection and management of the neuroleptic malignant syndrome". Clin Pharm. 3 (3): 302–7. PMID 6145537.
- ↑ S. Fahn, S. B. Bressman & C. D. Marsden (1998). "Classification of dystonia". Advances in neurology. 78: 1–10. PMID 9750897.
- ↑ Howard L. Geyer & Susan B. Bressman (2006). "The diagnosis of dystonia". The Lancet. Neurology. 5 (9): 780–790. doi:10.1016/S1474-4422(06)70547-6. PMID 16914406. Unknown parameter
|month=
ignored (help) - ↑ Christine Klein & Laurie J. Ozelius (2002). "Dystonia: clinical features, genetics, and treatment". Current opinion in neurology. 15 (4): 491–497. PMID 12151848. Unknown parameter
|month=
ignored (help) - ↑ Chow E, Troy SB (2014). "The differential diagnosis of hypoglycorrhachia in adult patients". Am J Med Sci. 348 (3): 186–90. doi:10.1097/MAJ.0000000000000217. PMC 4065645. PMID 24326618.
- ↑ Leen WG, Willemsen MA, Wevers RA, Verbeek MM (2012). "Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice". PLoS One. 7 (8): e42745. doi:10.1371/journal.pone.0042745. PMC 3412827. PMID 22880096.
- ↑ Charlotte Duverneuil, Geoffroy Lorin de la Grandmaison, Philippe de Mazancourt & Jean-Claude Alvarez (2004). "Liquid chromatography/photodiode array detection for determination of strychnine in blood: a fatal case report". Forensic science international. 141 (1): 17–21. doi:10.1016/j.forsciint.2003.12.010. PMID 15066709. Unknown parameter
|month=
ignored (help) - ↑ B. A. Smith (1990). "Strychnine poisoning". The Journal of emergency medicine. 8 (3): 321–325. PMID 2197324. Unknown parameter
|month=
ignored (help) - ↑ B. J. Maron, J. R. Krupp & B. Tune (1971). "Strychnine poisoning successfully treated with diazepam". The Journal of pediatrics. 78 (4): 697–699. PMID 5547830. Unknown parameter
|month=
ignored (help) - ↑ B. Oberpaur, A. Donoso, C. Claveria, C. Valverde & M. Azocar (1999). "Strychnine poisoning: an uncommon intoxication in children". Pediatric emergency care. 15 (4): 264–265. PMID 10460082. Unknown parameter
|month=
ignored (help)