Mucormycosis secondary prevention: Difference between revisions
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[[Posaconazole]] has been found to be an effective agent for secondary prevention of mucormycosis. | [[Posaconazole]] has been found to be an effective agent for secondary prevention of mucormycosis. | ||
== Secondary Prevention in Mucormycosis== | == Secondary Prevention in Mucormycosis== | ||
*Patients who respond to a parenteral lipid [[amphotericin B]]-based treatment, given for at least 3 weeks, are transitioned to oral [[posaconazole]] as maintenance/secondary prophylaxis with serial monitoring of [[posaconazole]] serum drug concentrations to ensure compliance and absorption of the antifungal.<ref name="pmid21622653">{{cite journal |vauthors=Kontoyiannis DP, Lewis RE |title=How I treat mucormycosis |journal=Blood |volume=118 |issue=5 |pages=1216–24 |year=2011 |pmid=21622653 |pmc=3292433 |doi=10.1182/blood-2011-03-316430 |url=}}</ref> | *Patients who respond to a [[parenteral]] [[lipid]] [[amphotericin B]]-based treatment, given for at least 3 weeks, are transitioned to oral [[posaconazole]] as maintenance/secondary prophylaxis with serial monitoring of [[posaconazole]] serum drug concentrations to ensure compliance and absorption of the antifungal.<ref name="pmid21622653">{{cite journal |vauthors=Kontoyiannis DP, Lewis RE |title=How I treat mucormycosis |journal=Blood |volume=118 |issue=5 |pages=1216–24 |year=2011 |pmid=21622653 |pmc=3292433 |doi=10.1182/blood-2011-03-316430 |url=}}</ref> | ||
*Lipid [[amphotericin B]] may achieve high levels in the human tissues, thus, intermittent doses of lipid [[amphotericin B]] ( | *Lipid [[amphotericin B]] may achieve high levels in the human tissues, thus, intermittent doses of lipid [[amphotericin B]] (i.e., 5 mg/kg 3 times per week or possibly even 2 times per week) after at least 3 to 4 weeks of initial therapy as an alternative to [[posaconazole]] therapy may also be used. | ||
==References== | ==References== | ||
Revision as of 14:33, 3 July 2017
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Mucormycosis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Posaconazole has been found to be an effective agent for secondary prevention of mucormycosis.
Secondary Prevention in Mucormycosis
- Patients who respond to a parenteral lipid amphotericin B-based treatment, given for at least 3 weeks, are transitioned to oral posaconazole as maintenance/secondary prophylaxis with serial monitoring of posaconazole serum drug concentrations to ensure compliance and absorption of the antifungal.[1]
- Lipid amphotericin B may achieve high levels in the human tissues, thus, intermittent doses of lipid amphotericin B (i.e., 5 mg/kg 3 times per week or possibly even 2 times per week) after at least 3 to 4 weeks of initial therapy as an alternative to posaconazole therapy may also be used.
References
- ↑ Kontoyiannis DP, Lewis RE (2011). "How I treat mucormycosis". Blood. 118 (5): 1216–24. doi:10.1182/blood-2011-03-316430. PMC 3292433. PMID 21622653.