Hirschsprung's disease other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies include rectal [[biopsy]], barium enema, and [[anorectal]] [[manometry]]. A rectal biopsy showing | Other diagnostic studies include: rectal [[biopsy]], [[barium enema]], and [[anorectal]] [[manometry]]. A rectal biopsy, showing ganglionic cells absence, is the gold standard confirmatory test for Hirschsprung's disease.<ref name="pmid25448783">{{cite journal |vauthors=Wetherill C, Sutcliffe J |title=Hirschsprung disease and anorectal malformation |journal=Early Hum. Dev. |volume=90 |issue=12 |pages=927–32 |year=2014 |pmid=25448783 |doi=10.1016/j.earlhumdev.2014.09.016 |url=}}</ref><ref name="pmid28600660">{{cite journal |vauthors=Das K, Mohanty S |title=Hirschsprung Disease - Current Diagnosis and Management |journal=Indian J Pediatr |volume= |issue= |pages= |year=2017 |pmid=28600660 |doi=10.1007/s12098-017-2371-8 |url=}}</ref> | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
A rectal [[biopsy]] | A rectal [[biopsy]], presenting the absence of ganglionic cells, is the gold standard confirmatory test for Hirschsprung's disease.<ref name="pmid25448783">{{cite journal |vauthors=Wetherill C, Sutcliffe J |title=Hirschsprung disease and anorectal malformation |journal=Early Hum. Dev. |volume=90 |issue=12 |pages=927–32 |year=2014 |pmid=25448783 |doi=10.1016/j.earlhumdev.2014.09.016 |url=}}</ref><ref name="pmid28600660">{{cite journal |vauthors=Das K, Mohanty S |title=Hirschsprung Disease - Current Diagnosis and Management |journal=Indian J Pediatr |volume= |issue= |pages= |year=2017 |pmid=28600660 |doi=10.1007/s12098-017-2371-8 |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
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|Rectal biopsy | |Rectal biopsy | ||
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* Absence of [[ganglion cells]] | * Absence of [[ganglion cells|ganglionic cells]] | ||
* Presence of thickened, unmyelinated [[nerves]] | * Presence of thickened, unmyelinated [[nerves]] | ||
* Increased activity of [[acetylcholinesterase]]; absence of nicotinamide adenine dinucleotide phosphate diaphorase-containing neurons | * Increased activity of [[acetylcholinesterase]]; absence of nicotinamide adenine dinucleotide phosphate (NADP) diaphorase-containing neurons | ||
* Increase in the amount of [[acetylcholinesterase]]-containing nerve bundles | * Increase in the amount of [[acetylcholinesterase]]-containing nerve bundles | ||
|- | |- | ||
|[[Enema]] | |[[Enema]] | ||
| | | | ||
* Contracted distal bowel and dilated proximal [[bowel]], with demonstration | * Contracted distal bowel and dilated proximal [[bowel]], with demonstration of the transition zone location in between | ||
|- | |- | ||
|[[Anorectal]] [[manometry]] | |[[Anorectal]] [[manometry]] | ||
Revision as of 18:03, 27 July 2017
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Hirschsprung's disease Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
Other diagnostic studies include: rectal biopsy, barium enema, and anorectal manometry. A rectal biopsy, showing ganglionic cells absence, is the gold standard confirmatory test for Hirschsprung's disease.[1][2]
Other Diagnostic Studies
A rectal biopsy, presenting the absence of ganglionic cells, is the gold standard confirmatory test for Hirschsprung's disease.[1][2]
| Diagnostic Test | FIndings |
|---|---|
| Rectal biopsy |
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| Enema |
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| Anorectal manometry |
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References
- ↑ 1.0 1.1 Wetherill C, Sutcliffe J (2014). "Hirschsprung disease and anorectal malformation". Early Hum. Dev. 90 (12): 927–32. doi:10.1016/j.earlhumdev.2014.09.016. PMID 25448783.
- ↑ 2.0 2.1 Das K, Mohanty S (2017). "Hirschsprung Disease - Current Diagnosis and Management". Indian J Pediatr. doi:10.1007/s12098-017-2371-8. PMID 28600660.