Echinococcosis medical therapy: Difference between revisions

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{{CMG}} '''Associate Editor-In-Chief:''' {{CZ}}
{{CMG}} '''Associate Editor-In-Chief:''' {{CZ}}
==Overview==
==Overview==
Both cystic echinococcosis and alveolar echinococcosis are complicated to treat, sometimes requiring extensive surgery and/or prolonged drug therapy. There are 3 options for the treatment of cystic echinococcosis anti-infective drug treatment, percutaneous treatment of the hydatid cysts with the PAIR (Puncture, Aspiration, Injection, Re-aspiration) technique and surgery.<ref name="pmid27729953">{{cite journal |vauthors=Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S, Bozkurt E |title=Current status of diagnosis and treatment of hepatic echinococcosis |journal=World J Hepatol |volume=8 |issue=28 |pages=1169–1181 |year=2016 |pmid=27729953 |pmc=5055586 |doi=10.4254/wjh.v8.i28.1169 |url=}}</ref>
Both [[cystic echinococcosis]] and [[alveolar echinococcosis]] are complicated to treat, sometimes requiring extensive surgery and/or prolonged drug therapy. There are 3 options for the treatment of cystic echinococcosis: anti-infective drug treatment, [[percutaneous]] treatment of the [[Hydatid cyst|hydatid cysts]] with the PAIR (Puncture, Aspiration, [[Injection (medicine)|Injection]], Re-aspiration) technique and surgery.<ref name="pmid27729953">{{cite journal |vauthors=Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S, Bozkurt E |title=Current status of diagnosis and treatment of hepatic echinococcosis |journal=World J Hepatol |volume=8 |issue=28 |pages=1169–1181 |year=2016 |pmid=27729953 |pmc=5055586 |doi=10.4254/wjh.v8.i28.1169 |url=}}</ref>


==Medical Therapy==
==Medical Therapy==
'''Cystic echinococcosis stage 1 of less than 5 cm'''
'''Cystic echinococcosis stage 1 of less than 5 cm'''
*Preferred regimen: Albendazole 10 to 15 mg/kg per day q12
*Preferred regimen: [[Albendazole]] 10 to 15 mg/kg per day q12
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
'''Cystic echinococcosis  stage 1 of more than 5 cm'''
'''Cystic echinococcosis  stage 1 of more than 5 cm'''
*Preferred regimen: Albendazole 10 to 15 mg/kg per day q12 '''and''' Puncture, Aspiration, Injection, Re-aspiration (PAIR)
*Preferred regimen: [[Albendazole]] 10 to 15 mg/kg per day q12 '''and''' Puncture, Aspiration, Injection, Re-aspiration (PAIR)
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
'''Cystic echinococcosis stage 2 of any size'''
'''Cystic echinococcosis stage 2 of any size'''
*Preferred regimen: Albendazole 10 to 15 mg/kg per day q12 '''and''' either modified catheterization or surgery
*Preferred regimen: [[Albendazole]] 10 to 15 mg/kg per day q12 '''and''' either modified [[catheterization]] or surgery
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
'''Cystic echinococcosis stage 3 of any size'''
'''Cystic echinococcosis stage 3 of any size'''
*Preferred regimen: Albendazole 10 to 15 mg/kg per day q12 '''and''' either modified catheterization or surgery
*Preferred regimen: [[Albendazole]] 10 to 15 mg/kg per day q12 '''and''' either modified [[catheterization]] or surgery
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)
*Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)



Revision as of 20:24, 24 July 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Both cystic echinococcosis and alveolar echinococcosis are complicated to treat, sometimes requiring extensive surgery and/or prolonged drug therapy. There are 3 options for the treatment of cystic echinococcosis: anti-infective drug treatment, percutaneous treatment of the hydatid cysts with the PAIR (Puncture, Aspiration, Injection, Re-aspiration) technique and surgery.[1]

Medical Therapy

Cystic echinococcosis stage 1 of less than 5 cm

  • Preferred regimen: Albendazole 10 to 15 mg/kg per day q12
  • Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)

Cystic echinococcosis stage 1 of more than 5 cm

  • Preferred regimen: Albendazole 10 to 15 mg/kg per day q12 and Puncture, Aspiration, Injection, Re-aspiration (PAIR)
  • Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)

Cystic echinococcosis stage 2 of any size

  • Preferred regimen: Albendazole 10 to 15 mg/kg per day q12 and either modified catheterization or surgery
  • Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)

Cystic echinococcosis stage 3 of any size

  • Preferred regimen: Albendazole 10 to 15 mg/kg per day q12 and either modified catheterization or surgery
  • Alternative regimen: Puncture, Aspiration, Injection, Re-aspiration (PAIR)

References

  1. Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S, Bozkurt E (2016). "Current status of diagnosis and treatment of hepatic echinococcosis". World J Hepatol. 8 (28): 1169–1181. doi:10.4254/wjh.v8.i28.1169. PMC 5055586. PMID 27729953.

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