Hantavirus infection natural history, complications and prognosis: Difference between revisions
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*In contrast to septic shock, HPS patients have a low cardiac output with a raised systemic vascular resistance. Poor prognostic indicators include a plasma lactate of greater than 4.0 mmol/L or a cardiac index of less than 2.2 L/min/m2 Whilst pulmonary edema and pleural effusions are common, [[multiorgan dysfunction syndrome]] is rarely seen. *However, HPS patients sometimes have mildly impaired renal function. Survivors frequently become polyuric during convalescence and improve almost as rapidly as they decompensated. | *In contrast to septic shock, HPS patients have a low cardiac output with a raised systemic vascular resistance. Poor prognostic indicators include a plasma lactate of greater than 4.0 mmol/L or a cardiac index of less than 2.2 L/min/m2 Whilst pulmonary edema and pleural effusions are common, [[multiorgan dysfunction syndrome]] is rarely seen. *However, HPS patients sometimes have mildly impaired renal function. Survivors frequently become polyuric during convalescence and improve almost as rapidly as they decompensated. | ||
==Complications== | ==Complications== | ||
Complications that can develop as a result of Hantavirus infection depends on the type of infection and can be summarized in the following table | Complications that can develop as a result of Hantavirus infection depends on the type of infection and can be summarized in the following table.<ref name="pmid28120221">{{cite journal |vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X |title=Hantavirus infection: a global zoonotic challenge |journal=Virol Sin |volume=32 |issue=1 |pages=32–43 |year=2017 |pmid=28120221 |doi=10.1007/s12250-016-3899-x |url=}}</ref> | ||
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Revision as of 19:35, 7 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Natural History
- Within 24 hours of initial evaluation, most patients develop some degree of hypotension and progressive evidence of pulmonary edema and hypoxia, usually requiring mechanical ventilation.
- The patients with fatal infections appear to have severe myocardial depression which can progress to sinus bradycardia with subsequent electromechanical dissociation, ventricular tachycardia or fibrillation.
- Hemodynamic compromise occurs a median of 5 days after symptom onset--usually dramatically within the first day of hospitalization.
- In contrast to HFRS, overt hemorrhage occurs rarely in HPS, although hemorrhage is occasionally seen in association with disseminated intravascular coagulation.
- In contrast to septic shock, HPS patients have a low cardiac output with a raised systemic vascular resistance. Poor prognostic indicators include a plasma lactate of greater than 4.0 mmol/L or a cardiac index of less than 2.2 L/min/m2 Whilst pulmonary edema and pleural effusions are common, multiorgan dysfunction syndrome is rarely seen. *However, HPS patients sometimes have mildly impaired renal function. Survivors frequently become polyuric during convalescence and improve almost as rapidly as they decompensated.
Complications
Complications that can develop as a result of Hantavirus infection depends on the type of infection and can be summarized in the following table.[1]
| Type of hantavirus infection | Complications |
|---|---|
| Hemorrhagic fever with renal syndrome (HFRS) |
|
| Hantavirus cardiopulmonary syndrome (HCPS |
|
References
- ↑ Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X (2017). "Hantavirus infection: a global zoonotic challenge". Virol Sin. 32 (1): 32–43. doi:10.1007/s12250-016-3899-x. PMID 28120221.