Chronic diarrhea medical therapy: Difference between revisions
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==Medical Therapy== | ==Medical Therapy== | ||
For the treatment of the most common causes of chronic diarrhea, please see below; | For the treatment of the most common causes of chronic diarrhea, please see below; | ||
*Inflammatory diarrhea | *'''Inflammatory diarrhea''' | ||
**[[Crohn's disease medical therapy#Medical Therapy|Chrohn's disease]] | **[[Crohn's disease medical therapy#Medical Therapy|Chrohn's disease]] | ||
**[[Ulcerative colitis medical therapy#Medical Therapy|Ulcerative Colitis]] | **[[Ulcerative colitis medical therapy#Medical Therapy|Ulcerative Colitis]] | ||
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**[[Ischemic colitis medical therapy#Medical Therapy|Ischemic Colitis]] | **[[Ischemic colitis medical therapy#Medical Therapy|Ischemic Colitis]] | ||
*Watery diarrhea | *'''Watery diarrhea''' | ||
**[[Celiac disease medical therapy#Medical Therapy|Celiac sprue]] | **[[Celiac disease medical therapy#Medical Therapy|Celiac sprue]] | ||
**[[Chronic pancreatitis medical therapy#Medical Therapy|Chronic pancreatitis]] | **[[Chronic pancreatitis medical therapy#Medical Therapy|Chronic pancreatitis]] | ||
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**[[Addison's disease medical therapy#Medical Therapy|Addison's disease]] | **[[Addison's disease medical therapy#Medical Therapy|Addison's disease]] | ||
*Fatty diarrhea | *'''Fatty diarrhea''' | ||
**[[Celiac disease medical therapy#Medical Therapy|Celiac disease]] | **[[Celiac disease medical therapy#Medical Therapy|Celiac disease]] | ||
**[[Pancreatic insufficiency#Treatment|Pancreatic insufficiency]] | **[[Pancreatic insufficiency#Treatment|Pancreatic insufficiency]] | ||
Revision as of 12:16, 10 July 2017
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Chronic diarrhea Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
Antidiarrheal drugs can be broadly defined as agents that minimize the symptoms of diarrhea by improving stool consistency, reducing stool frequency, or reducing stool weight.[1]
Medical Therapy
For the treatment of the most common causes of chronic diarrhea, please see below;
- Inflammatory diarrhea
- Watery diarrhea
Some antidiarrheal drugs are prescribed depending on the underlying mechanism for example, in a patient with Zollinger-ellison syndrome (ZES) where hypersecretion of gastrin is the underlying cause of the diarrhea, proton pump inhibitors can be used. This drugs are used primarily for symptomatic relief prior to identifying the cause of the diarrhea[1] Below are some of the drugs that can be used in the symptomatic treatment of chronic diarrhea and some of their mechanisms of actions. Some drugs have numerous mechanisms of action and can thus be found under more than one sections. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.
Inhibitors of intestinal transit time
- Opiates
- Encephalinase inhibitor
- 5-HT3-receptor antagonist
- α2-Adrenergic agonist
- Somatostatin and analogs
- Calcium channel blocker
Pro-absorptive agents
Antisecretory drugs
- Somatostatin and analogs
- Enterocyte apical membrane chloride channel inhibitors
- Berberine
- Calcium channel blockers
- Calmodulin inhibitors
- Calcium-sensing receptor ligands
- Nicotinic acid
- Lithium
- Zinc
- Bismuth
- Nonsteroidal antiinflammatory drugs
- Corticosteroids
- Teduglutide
Intraluminal agents
- Adsorbents
- Clays
- Bile acid-binding resins
- Fiber
References
- ↑ 1.0 1.1 Schiller LR (1995). "Review article: anti-diarrhoeal pharmacology and therapeutics". Aliment Pharmacol Ther. 9 (2): 87–106. PMID 7605866.