Addison's disease differential diagnosis: Difference between revisions
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{| class="wikitable" | {| class="wikitable" | ||
! | ! | ||
! | !Harmone or pathway defective | ||
! | ! | ||
! | ! | ||
|- | |- | ||
|ACTH deficiency | |ACTH deficiency | ||
| | |↓ ACTH | ||
| | |Pituitary gland | ||
| | | | ||
|- | |- | ||
|Congenital adrenal hyperplasia (CAH) | |Congenital adrenal hyperplasia (CAH) | ||
| | |↓ Corticosteroid hormones | ||
| | |Adrenal gland | ||
| | | | ||
|- | |- | ||
|Adrenoleukodystrophy | |Adrenoleukodystrophy | ||
| | |ABCD1 gene on the X chromosome | ||
| | |White matter of the nervous system and | ||
the adrenal cortex | |||
| | | | ||
|- | |- | ||
|Autoimmune polyendocrine syndrome type II | |Autoimmune polyendocrine syndrome type II | ||
( Schmidt syndrome) | ( Schmidt syndrome) | ||
| | |↓Parathyroid harmone | ||
| | |||
↓Insulin | |||
↓Sex harmones | |||
|parathyroid gland | |||
Pancreas | |||
Gonads | |||
| | | | ||
|- | |- | ||
|Autoimmune polyendocrine syndrome type I, (APS type 1) | |Autoimmune polyendocrine syndrome type I, (APS type 1) | ||
( APECED syndrome) | ( APECED syndrome) | ||
| | |Autoimmune Polyendocrinopathy (APE), Candidiasis (C) and Ectodermal Dysplasia (ED) | ||
| | |Autoimmune Polyendocrinopathy (APE) | ||
Candidiasis (C) | |||
Ectodermal Dysplasia (ED) | |||
| | | | ||
|- | |- | ||
Revision as of 21:51, 17 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differentiating Addison's disease from other Diseases
Addison's disease should be differentiated from the following diseases:
- Acanthosis nigricans
- Anorexia nervosa
- Chronic fatigue syndrome
- Depression
- Disorders of oral pigmentation
- Hyperthyroidism
- Laugier-Hunziker Syndrome
- Lentigo
- Malignant melanoma
- Melasma
- Occult malignancy
- Oral manifestations of systemic diseases
- Peutz-Jeghers syndrome
- Type 1 diabetes mellitus
- Vitiligo
| Harmone or pathway defective | |||
|---|---|---|---|
| ACTH deficiency | ↓ ACTH | Pituitary gland | |
| Congenital adrenal hyperplasia (CAH) | ↓ Corticosteroid hormones | Adrenal gland | |
| Adrenoleukodystrophy | ABCD1 gene on the X chromosome | White matter of the nervous system and
the adrenal cortex |
|
| Autoimmune polyendocrine syndrome type II
( Schmidt syndrome) |
↓Parathyroid harmone
↓Insulin ↓Sex harmones |
parathyroid gland
Pancreas Gonads |
|
| Autoimmune polyendocrine syndrome type I, (APS type 1)
( APECED syndrome) |
Autoimmune Polyendocrinopathy (APE), Candidiasis (C) and Ectodermal Dysplasia (ED) | Autoimmune Polyendocrinopathy (APE)
Candidiasis (C) Ectodermal Dysplasia (ED) |
|
| Hemachromatosis | |||
| Hyperthyroidism |