Thyroid nodule causes: Difference between revisions
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==Overview== | ==Overview== | ||
== Causes == | == Causes == | ||
* | * Causes of benign thyroid nodule: | ||
** Multinodular (sporadic) goiter ("colloid adenoma") | ** Multinodular (sporadic) goiter ("colloid adenoma") | ||
** Hashimoto's (chronic lymphocytic) thyroiditis | ** Hashimoto's (chronic lymphocytic) thyroiditis | ||
Line 14: | Line 14: | ||
** Hürthle cell (oxyphil cell) adenomas | ** Hürthle cell (oxyphil cell) adenomas | ||
** Macro- or microfollicular patterns | ** Macro- or microfollicular patterns | ||
* | * Causes of malignant nodule mutations: | ||
** | ** Childhood radioiodine exposure | ||
** | ** Familial history | ||
** | * The most important genes that can cause thyroid cancer include: | ||
** | ** ''N&H ras'' | ||
** | ** RET | ||
** | ** Gsp | ||
** | ** C-MET (α and β subunit) | ||
** | ** TRK | ||
** | ** EGF / EGF-R | ||
** P53 | |||
==References== | ==References== |
Revision as of 12:05, 15 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
- Causes of benign thyroid nodule:
- Multinodular (sporadic) goiter ("colloid adenoma")
- Hashimoto's (chronic lymphocytic) thyroiditis
- Cysts (colloid, simple, or hemorrhagic)
- Follicular adenomas
- Macrofollicular adenomas
- Microfollicular or cellular adenomas
- Hürthle cell (oxyphil cell) adenomas
- Macro- or microfollicular patterns
- Causes of malignant nodule mutations:
- Childhood radioiodine exposure
- Familial history
- The most important genes that can cause thyroid cancer include:
- N&H ras
- RET
- Gsp
- C-MET (α and β subunit)
- TRK
- EGF / EGF-R
- P53