Leukemia: Difference between revisions
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==Differentiating Leukemia from other Diseases== | ==Differentiating Leukemia from other Diseases== | ||
==Epidemiology and Demographics== | |||
===Prevalence=== | |||
* In the United States, the age-adjusted [[prevalence]] of leukemia is 75.3 per 100,000 in 2011.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
===Incidence=== | |||
* The delay-adjusted [[incidence]] of leukemia in 2011 was estimated to be 15.48 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
* In 2011, the age-adjusted [[incidence]] of leukemia was 13.66 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
===Age=== | |||
* The overall age-adjusted [[incidence]] of leukemia in the United States between 2007 and 2011 is 13 per 100,000, the age-adjusted [[incidence]] of leukemia by age category is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
** Under 65 years: 6.5 per 100,000 | |||
** 65 and over: 57.9 per 100,000 | |||
* Shown below is a table depicting the overall age-adjusted [[incidence]] of leukemia per 100,000 individuals by age in the United States between 2007 and 2011 for the different types of leukemia.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
{| style="cellpadding=0; cellspacing= 0; width: 600px;" | |||
|- | |||
|style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | ||style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Acute lymphoblastic leukemia'''||style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | '''Chronic lymphocytic leukemia'''|| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Acute myeloid leukemia'''|| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Chronic myeloid leukemia''' | |||
|- | |||
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''All ages'''||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | 1.7 || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |4.4|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |3.8 || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |1.7 | |||
|- | |||
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''<65''' || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |1.7 ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |1.4||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | 1.8 || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |0.9 | |||
|- | |||
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''≥65''' ||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | 1.6 || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |25.2 || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |17.5||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |6.8 | |||
|} | |||
===Gender=== | |||
* In the United States, the age-adjusted [[prevalence]] of leukemia by gender in 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
** In males: 92.7 per 100,000 | |||
** In females: 60.7 per 100,000 | |||
* In the United States, the delay-adjusted [[incidence]] of leukemia by gender in 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
** In males: 19.93 per 100,000 persons | |||
** In females: 11.89 per 100,000 persons | |||
* In the United States, the age-adjusted [[incidence]] of leukemia by gender on 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
** In males: 17.58 per 100,000 persons | |||
** In females: 10.49 per 100,000 persons | |||
* Shown below is an image depicting the delay-adjusted [[incidence]] and observed [[incidence]] of leukemia by gender and race in the United States between 1975 and 2011. These graphs are adapted from [[SEER]]: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
[[Image:Incidence of leukemia by gender and race in USA.PNG|700px|Delay-adjusted [[incidence]] and observed [[incidence]] of leukemia by gender and race in the United States between 1975 and 2011]] | |||
===Race=== | |||
* Shown below is a table depicting the age-adjusted [[prevalence]] of leukemia by race in 2011 in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
{| style="cellpadding=0; cellspacing= 0; width: 600px;" | |||
|- | |||
|style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center | || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''All Races''' ||style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''White''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Black''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Asian/Pacific Islander''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Hispanic''' | |||
|- | |||
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align=center |'''Age-adjusted [[prevalence]]'''|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |75.3 per 100,000||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |83.5 per 100,000||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |45.9 per 100,000||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |41.2 per 100,000||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |57.1 per 100,000 | |||
|} | |||
* Shown below is an image depicting the [[incidence]] of leukemia by race in the United States between 1975 and 2011.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
[[Image:Incidence of leukemia by race in USA.PNG|Incidence of leukemia by race in the United States between 1975 and 2011]] | |||
<small> API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native</small> | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 13:50, 21 July 2017
Template:DiseaseDisorder infobox
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Leukemia Microchapters |
For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Leukaemia
Overview
Leukemia (Greek leukos, “white”; haima, “blood”) is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation (production by multiplication) of blood cells, usually white blood cells (leukocytes). It is part of the broad group of diseases called hematological neoplasms.
Classification
Differentiating Leukemia from other Diseases
Epidemiology and Demographics
Prevalence
- In the United States, the age-adjusted prevalence of leukemia is 75.3 per 100,000 in 2011.[1]
Incidence
- The delay-adjusted incidence of leukemia in 2011 was estimated to be 15.48 per 100,000 persons in the United States.[1]
- In 2011, the age-adjusted incidence of leukemia was 13.66 per 100,000 persons in the United States.[1]
Age
- The overall age-adjusted incidence of leukemia in the United States between 2007 and 2011 is 13 per 100,000, the age-adjusted incidence of leukemia by age category is:[1]
- Under 65 years: 6.5 per 100,000
- 65 and over: 57.9 per 100,000
- Shown below is a table depicting the overall age-adjusted incidence of leukemia per 100,000 individuals by age in the United States between 2007 and 2011 for the different types of leukemia.[1]
| Acute lymphoblastic leukemia | Chronic lymphocytic leukemia | Acute myeloid leukemia | Chronic myeloid leukemia | |
| All ages | 1.7 | 4.4 | 3.8 | 1.7 |
| <65 | 1.7 | 1.4 | 1.8 | 0.9 |
| ≥65 | 1.6 | 25.2 | 17.5 | 6.8 |
Gender
- In the United States, the age-adjusted prevalence of leukemia by gender in 2011 is:[1]
- In males: 92.7 per 100,000
- In females: 60.7 per 100,000
- In the United States, the delay-adjusted incidence of leukemia by gender in 2011 is:[1]
- In males: 19.93 per 100,000 persons
- In females: 11.89 per 100,000 persons
- In the United States, the age-adjusted incidence of leukemia by gender on 2011 is:[1]
- In males: 17.58 per 100,000 persons
- In females: 10.49 per 100,000 persons
- Shown below is an image depicting the delay-adjusted incidence and observed incidence of leukemia by gender and race in the United States between 1975 and 2011. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.[1]
Race
- Shown below is a table depicting the age-adjusted prevalence of leukemia by race in 2011 in the United States.[1]
| All Races | White | Black | Asian/Pacific Islander | Hispanic | |
| Age-adjusted prevalence | 75.3 per 100,000 | 83.5 per 100,000 | 45.9 per 100,000 | 41.2 per 100,000 | 57.1 per 100,000 |
- Shown below is an image depicting the incidence of leukemia by race in the United States between 1975 and 2011.[1]
API: Asian/Pacific Islander; AI/AN: American Indian/ Alaska Native
Prognosis
5-Year Survival
- Between 2004 and 2010, the 5-year relative survival of patients with leukemia was 60.3%.[1]
- When stratified by age, the 5-year relative survival of patients with leukemia was 68.5% and 44.1% for patients <65 and ≥ 65 years of age respectively.[1]
- Shown below is a table depicting the 5-year relative survival of patients by the type of leukemia in the United States between 2004 and 2010.
| Acute lymphoblastic leukemia | Chronic lymphocytic leukemia | Acute myeloid leukemia | Chronic myeloid leukemia | |
| 5-year survival | 70% | 83.5% | 25.4% | 59.9% |
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.