Psoriasis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
=== Biopsy<ref name="pmid18251745">{{cite journal |vauthors=Werner B, Bresch M, Brenner FM, Lima HC |title=Comparative study of histopathological and immunohistochemical findings in skin biopsies from patients with psoriasis before and after treatment with acitretin |journal=J. Cutan. Pathol. |volume=35 |issue=3 |pages=302–10 |year=2008 |pmid=18251745 |doi=10.1111/j.1600-0560.2007.00800.x |url=}}</ref> | === Biopsy === | ||
On [[H&E stain|Hemotoxylin and Eosin (H&E)]] stain the following findings may be observed:<ref name="pmid18251745">{{cite journal |vauthors=Werner B, Bresch M, Brenner FM, Lima HC |title=Comparative study of histopathological and immunohistochemical findings in skin biopsies from patients with psoriasis before and after treatment with acitretin |journal=J. Cutan. Pathol. |volume=35 |issue=3 |pages=302–10 |year=2008 |pmid=18251745 |doi=10.1111/j.1600-0560.2007.00800.x |url=}}</ref> | |||
* Perivascular and [[dermal]] [[Inflammatory cells|inflammatory cell]] infiltration | * Perivascular and [[dermal]] [[Inflammatory cells|inflammatory cell]] infiltration | ||
* [[Vascular]] dilation | * [[Vascular]] dilation | ||
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* [[Basal cell layer]] is expanded | * [[Basal cell layer]] is expanded | ||
=== Enzyme linked immunosorbent assay (ELISA)<ref name="pmid16865225">{{cite journal |vauthors=Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G |title=Long pentraxin 3: a marker of inflammation in untreated psoriatic patients |journal=Int. J. Mol. Med. |volume=18 |issue=3 |pages=415–23 |year=2006 |pmid=16865225 |doi= |url=}}</ref> | === Enzyme linked immunosorbent assay (ELISA) === | ||
* In patients with severe psoriasis, increased levels of Long Pentraxin 3 protein (PTX3) are found in [[plasma]] and in [[monocytic]] cultures by [[Enzyme linked immunosorbent assay (ELISA)|enzyme linked immunosorbent assay]] (ELISA)<ref name="pmid16865225">{{cite journal |vauthors=Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G |title=Long pentraxin 3: a marker of inflammation in untreated psoriatic patients |journal=Int. J. Mol. Med. |volume=18 |issue=3 |pages=415–23 |year=2006 |pmid=16865225 |doi= |url=}}</ref> | |||
=== Serum complement levels<ref name="pmid6159678">{{cite journal |vauthors=Vinje O, Møller P, Mellbye OJ |title=Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis |journal=Scand. J. Rheumatol. |volume=9 |issue=2 |pages=97–105 |year=1980 |pmid=6159678 |doi= |url=}}</ref> | === Serum complement levels === | ||
The following abnormalities may be observed in [[Complement|serum complement]] levels in psoriasis:<ref name="pmid6159678">{{cite journal |vauthors=Vinje O, Møller P, Mellbye OJ |title=Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis |journal=Scand. J. Rheumatol. |volume=9 |issue=2 |pages=97–105 |year=1980 |pmid=6159678 |doi= |url=}}</ref> | |||
* Increased serum [[Immunoglobulin A|IgA]] | * Increased serum [[Immunoglobulin A|IgA]] | ||
* Increased [[C3 (complement)|C3]] in phalyngeal [[arthropathy]] associated with psoriasis | * Increased [[C3 (complement)|C3]] in phalyngeal [[arthropathy]] associated with psoriasis | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Laboratory findings consistent with the diagnosis of psoriasis include parakeratosis, vascular dilation, spongiform pustules of Kogoj and Munro's microabscesses on hemotoxylin and Eosin staining of an affected area of skin. ELISA may show increased levels of Long Pentraxin 3 protein (PTX3). Complement levels may be increased.
Laboratory Findings
Biopsy
On Hemotoxylin and Eosin (H&E) stain the following findings may be observed:[1]
- Perivascular and dermal inflammatory cell infiltration
- Vascular dilation
- Absent granular layer
- Elongation of dermal papillae
- Parakeratosis
- Spongiform pustules of Kogoj (Pathognomic of psoriasis)
- Munro's microabscesses (Pathognomic of psoriasis)
- Edema of dermal papillae
- In psoriasis, skin biopsy of the affected area of skin shows that the epidermal/suprapapillary thickness ratio is increased
- Basal cell layer is expanded
Enzyme linked immunosorbent assay (ELISA)
- In patients with severe psoriasis, increased levels of Long Pentraxin 3 protein (PTX3) are found in plasma and in monocytic cultures by enzyme linked immunosorbent assay (ELISA)[2]
Serum complement levels
The following abnormalities may be observed in serum complement levels in psoriasis:[3]
- Increased serum IgA
- Increased C3 in phalyngeal arthropathy associated with psoriasis
- Increased C4
- Increased C3PA concentrations
- Increased CRP concentration in sacroiliitis associated with psoriasis
References
- ↑ Werner B, Bresch M, Brenner FM, Lima HC (2008). "Comparative study of histopathological and immunohistochemical findings in skin biopsies from patients with psoriasis before and after treatment with acitretin". J. Cutan. Pathol. 35 (3): 302–10. doi:10.1111/j.1600-0560.2007.00800.x. PMID 18251745.
- ↑ Bevelacqua V, Libra M, Mazzarino MC, Gangemi P, Nicotra G, Curatolo S, Massimino D, Plumari A, Merito P, Valente G, Stivala F, La Greca S, Malaponte G (2006). "Long pentraxin 3: a marker of inflammation in untreated psoriatic patients". Int. J. Mol. Med. 18 (3): 415–23. PMID 16865225.
- ↑ Vinje O, Møller P, Mellbye OJ (1980). "Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis". Scand. J. Rheumatol. 9 (2): 97–105. PMID 6159678.