Diabetes insipidus risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
===Common Risk Factors=== | |||
The following are some of the common risk factors associated with the development of diabetes insipidus:<ref name="pmid15806465">{{cite journal |vauthors=Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF |title=Causes of reversible nephrogenic diabetes insipidus: a systematic review |journal=Am. J. Kidney Dis. |volume=45 |issue=4 |pages=626–37 |year=2005 |pmid=15806465 |doi= |url=}}</ref><ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref><ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref><ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref><ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref><ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref> | |||
*[[Genetics]] | |||
*[[Polycystic kidney disease|Polycystic kidney disease]] | |||
*[[Pituitary disease|Pituitary disorders]] | |||
*[[Hypothalamic dysfunction|Hypothalamic injury]] | *[[Hypothalamic dysfunction|Hypothalamic injury]] | ||
*[[Hypercalcemia]] | *[[Hypercalcemia]] | ||
*Head [[ | *Head [[tumors]] | ||
*[[Pregnancy]] | *[[Pregnancy]] | ||
*[[Sickle-cell disease|Sickle cell disease]] | *[[Sickle-cell disease|Sickle cell disease]] | ||
*[[Amyloidosis]] | *[[Amyloidosis]] | ||
*Lithium use | |||
===Less Common Risk Factors=== | |||
Some less common risk factors are: | |||
*Male Gender- some types of [[nephrogenic diabetes insipidus]] have a male predisposition i.e diabetes insipidus caused by [[Aquaporin 2|AQP2]] mutations | *Male Gender- some types of [[nephrogenic diabetes insipidus]] have a male predisposition i.e diabetes insipidus caused by [[Aquaporin 2|AQP2]] mutations | ||
*Family History of [[nephrogenic diabetes insipidus]] | *Family History of [[nephrogenic diabetes insipidus]] | ||
*Excessive water consumption | *Excessive water consumption | ||
*[[pregnancy]] | *[[pregnancy]] | ||
*Drugs like phenothiazine | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
The risk factors in the development of diabetes insipidus vary depending on the type of diabetes insipidus being described. There are a few risk factors in the development of central diabetes which include genetic mutations, pituitary disorders, hypothalamic injury, and head tumors. The most potent risk factor in the development of nephrogenic diabetes insipidus is lithium use as lithium has a very narrow therapeutic index of 0.4-0.8. Excessive water intake has been identified to be the only risk factor associated with psychogenic diabetes insipidus and pregnancy for gestational diabetes insipidus.
Risk Factors
Common Risk Factors
The following are some of the common risk factors associated with the development of diabetes insipidus:[1][2][3][4][5][6]
- Genetics
- Polycystic kidney disease
- Pituitary disorders
- Hypothalamic injury
- Hypercalcemia
- Head tumors
- Pregnancy
- Sickle cell disease
- Amyloidosis
- Lithium use
Less Common Risk Factors
Some less common risk factors are:
- Male Gender- some types of nephrogenic diabetes insipidus have a male predisposition i.e diabetes insipidus caused by AQP2 mutations
- Family History of nephrogenic diabetes insipidus
- Excessive water consumption
- pregnancy
- Drugs like phenothiazine
References
- ↑ Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF (2005). "Causes of reversible nephrogenic diabetes insipidus: a systematic review". Am. J. Kidney Dis. 45 (4): 626–37. PMID 15806465.
- ↑ Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M (2000). "Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants". J. Clin. Invest. 105 (7): 887–95. doi:10.1172/JCI8688. PMC 377482. PMID 10749568.
- ↑ Devonald MA, Karet FE (2004). "Renal epithelial traffic jams and one-way streets". J. Am. Soc. Nephrol. 15 (6): 1370–81. PMID 15153548.
- ↑ Bichet DG (2006). "Hereditary polyuric disorders: new concepts and differential diagnosis". Semin. Nephrol. 26 (3): 224–33. doi:10.1016/j.semnephrol.2006.02.004. PMID 16713495.
- ↑ van Lieburg AF, Knoers NV, Monnens LA (1999). "Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus". J. Am. Soc. Nephrol. 10 (9): 1958–64. PMID 10477148.
- ↑ Bockenhauer D, Bichet DG (2015). "Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus". Nat Rev Nephrol. 11 (10): 576–88. doi:10.1038/nrneph.2015.89. PMID 26077742.