De Quervain's thyroiditis pathophysiology: Difference between revisions
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===Genetics=== | ===Genetics=== | ||
*De Quervain's thyroiditis is associated with | *De Quervain's thyroiditis is associated with: | ||
* | **The histocompatibility antigen (HLA) B35 | ||
**HLA B15/62 (in rare cases) | |||
===Pathology=== | ===Pathology=== | ||
The primary pathology of de Quervain's thyroiditis is: | The primary pathology of de Quervain's thyroiditis is:<ref name="pmid12608662">{{cite journal |vauthors=Kojima M, Nakamura S, Oyama T, Sugihara S, Sakata N, Masawa N |title=Cellular composition of subacute thyroiditis. an immunohistochemical study of six cases |journal=Pathol. Res. Pract. |volume=198 |issue=12 |pages=833–7 |year=2002 |pmid=12608662 |doi=10.1078/0344-0338-00344 |url=}}</ref> | ||
*Destruction of the follicular epithelium | *Destruction of the follicular epithelium | ||
*Loss of the follicular integrity | *Loss of the follicular integrity | ||
Revision as of 18:40, 1 August 2017
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De Quervain's thyroiditis Microchapters |
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Differentiating De Quervain's thyroiditis from other Diseases |
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Diagnosis |
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Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
The exact pathogenesis of de Quervain's thyroiditis is unclear. It is proposed that cytotoxic T cell recognition of viral and cell antigens presentation in a complex leads to the thyroid follicular cell damage which is responsible for the pathogenesis of de Quervain's thyroiditis. De Quervain's thyroiditis is usually preceded by a viral prodrome and also have a genetic predisposition. HLA B35 and HLA B15/62 are associated with de Quervain's thyroiditis.
Pathophysiology
Pathogenesis
The exact pathogenesis of de Quervain's thyroiditis is unclear. Cytotoxic T cell recognition of viral and cell antigens presented in a complex leading to thyroid follicular cell damage has been proposed as the pathogenesis of de Quervain's thyroiditis. De Quervain's thyroiditis is usually preceded by a viral prodrome. Various viral infections are associated with the de Quervain's thyroiditis including mumps, adenovirus, Epstein–Barr virus, coxsackievirus, cytomegalovirus, influenza, echovirus, and enterovirus.[1]
Genetics
- De Quervain's thyroiditis is associated with:
- The histocompatibility antigen (HLA) B35
- HLA B15/62 (in rare cases)
Pathology
The primary pathology of de Quervain's thyroiditis is:[1]
- Destruction of the follicular epithelium
- Loss of the follicular integrity