Glucagonoma epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
* Annual incidence is 0.01 to 0.1 new cases per 100,000.1 | * Annual incidence is 0.01 to 0.1 new cases per 100,000.<ref name="pmid22261919">{{cite journal| author=Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P et al.| title=ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes. | journal=Neuroendocrinology | year= 2012 | volume= 95 | issue= 2 | pages= 98-119 | pmid=22261919 | doi=10.1159/000335591 | pmc=3701449 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22261919 }}</ref> | ||
* While most glucagonomas are sporadic, up to 20 percent may be associated with the multiple endocrine neoplasia syndrome type 1. glucagonomas occur in only 3 percent of MEN1 patients.<ref name="pmid15657529">{{cite journal| author=Lévy-Bohbot N, Merle C, Goudet P, Delemer B, Calender A, Jolly D et al.| title=Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: study from the GTE (Groupe des Tumeurs Endocrines) registry. | journal=Gastroenterol Clin Biol | year= 2004 | volume= 28 | issue= 11 | pages= 1075-81 | pmid=15657529 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15657529 }}</ref> | |||
* Patients typically present in their fifth decade.<ref name="pmid8606627">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }}</ref> | |||
* Patients typically present in their fifth decade | |||
*Fewer than 251 cases of glucagonoma have been described in the literature. | *Fewer than 251 cases of glucagonoma have been described in the literature. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
The incidence of glucagonoma is approximately 0.0005 per 100,000 individuals worldwide. Glucagonoma affects men and women equally. The median age at diagnosis of glucagonoma is 52.5 years.
Epidemiology and Demographics
- Annual incidence is 0.01 to 0.1 new cases per 100,000.[1]
- While most glucagonomas are sporadic, up to 20 percent may be associated with the multiple endocrine neoplasia syndrome type 1. glucagonomas occur in only 3 percent of MEN1 patients.[2]
- Patients typically present in their fifth decade.[3]
- Fewer than 251 cases of glucagonoma have been described in the literature.
- Glucagonoma affects men and women equally.
References
- ↑ Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P; et al. (2012). "ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes". Neuroendocrinology. 95 (2): 98–119. doi:10.1159/000335591. PMC 3701449. PMID 22261919.
- ↑ Lévy-Bohbot N, Merle C, Goudet P, Delemer B, Calender A, Jolly D; et al. (2004). "Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: study from the GTE (Groupe des Tumeurs Endocrines) registry". Gastroenterol Clin Biol. 28 (11): 1075–81. PMID 15657529.
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.