Glucagonoma natural history, complications and prognosis: Difference between revisions
No edit summary |
No edit summary |
||
| Line 12: | Line 12: | ||
==Prognosis== | ==Prognosis== | ||
* Glucagonomas are generally slow-growing but are usually advanced by the time of diagnosis. | * Glucagonomas are generally slow-growing but are usually advanced by the time of diagnosis. | ||
* Age, grade, and distant metastases are the most significant predictors of survival. | * [[Age]], [[grade]], and distant [[metastases]] are the most significant predictors of survival. | ||
* Five and 10-year survival rates for patients undergoing resection of gastroenteropancreatic [[neuroendocrine tumors]].<ref name="pmid8606627">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }}</ref> | * Five and 10-year survival rates for patients undergoing resection of gastroenteropancreatic [[neuroendocrine tumors]].<ref name="pmid8606627">{{cite journal| author=Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV| title=The glucagonoma syndrome. Clinical and pathologic features in 21 patients. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 2 | pages= 53-63 | pmid=8606627 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8606627 }}</ref> | ||
* Sixty percent of glucagonomas are [[malignant]]. Once the tumor is [[Metastasis|metastatic]], the cure is rare. | * Sixty percent of glucagonomas are [[malignant]]. Once the tumor is [[Metastasis|metastatic]], the cure is rare. | ||
Prognosis of glucagonoma depends on the following: | Prognosis of glucagonoma depends on the following: | ||
*Whether or not the tumor can be removed by surgery | *Whether or not the tumor can be removed by surgery | ||
*The [[stage of the tumor]], the size of the tumor, whether cancer has spread outside the pancreas | *The [[stage of the tumor]], the size of the tumor, whether cancer has spread outside [[the pancreas]] | ||
*The patient’s general health | *The patient’s general health | ||
*Whether the tumor has just been diagnosed or has recurred | *Whether the tumor has just been diagnosed or has recurred | ||
*The presence of metastasis is associated with a particularly poor prognosis among patients with glucagonoma. | *The presence of metastasis is associated with a particularly poor prognosis among patients with glucagonoma. | ||
*The 10-year event free [[survival rate]] is less than 51.6% with metastasis and 64.3% without metastasis. | *The 10-year event free [[survival rate]] is less than 51.6% with [[metastasis]] and 64.3% without metastasis. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:01, 4 August 2017
|
Glucagonoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Glucagonoma natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Glucagonoma natural history, complications and prognosis |
|
FDA on Glucagonoma natural history, complications and prognosis |
|
CDC on Glucagonoma natural history, complications and prognosis |
|
Glucagonoma natural history, complications and prognosis in the news |
|
Blogs on Glucagonoma natural history, complications and prognosis |
|
Risk calculators and risk factors for Glucagonoma natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2] Mohammed Abdelwahed M.D[3]
Overview
If left untreated, patients with glucagonoma may progress to develop necrolytic migratory erythema, cheilosis, stomatitis, diarrhea, polyuria, and polydipsia. The presence of metastasis is associated with a particularly poor prognosis among patients with glucagonoma. The 10-year event free survival rate is less than 51.6% with metastasis and 64.3% without metastasis. Glucagonomas are generally slow-growing but are usually advanced by the time of diagnosis. Age, grade, and distant metastases are the most significant predictors of survival.
Natural History
- If left untreated, patients with glucagonoma may progress to develop necrolytic migratory erythema, cheilosis, stomatitis, diarrhea, polyuria, and polydipsia.
- Glucagonoma has a very slow growth rate compared to most malignant tumors.
Prognosis
- Glucagonomas are generally slow-growing but are usually advanced by the time of diagnosis.
- Age, grade, and distant metastases are the most significant predictors of survival.
- Five and 10-year survival rates for patients undergoing resection of gastroenteropancreatic neuroendocrine tumors.[1]
- Sixty percent of glucagonomas are malignant. Once the tumor is metastatic, the cure is rare.
Prognosis of glucagonoma depends on the following:
- Whether or not the tumor can be removed by surgery
- The stage of the tumor, the size of the tumor, whether cancer has spread outside the pancreas
- The patient’s general health
- Whether the tumor has just been diagnosed or has recurred
- The presence of metastasis is associated with a particularly poor prognosis among patients with glucagonoma.
- The 10-year event free survival rate is less than 51.6% with metastasis and 64.3% without metastasis.
References
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.