De Quervain's thyroiditis other diagnostic studies

De Quervain's thyroiditis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating De Quervain's thyroiditis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary prevention
Secondary prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The histological analysis in de Quervain's thyroiditis may show inflammatory cell infiltration and hurthle cells. Fine needle aspiration cytology helps to differentiate between the benign and malignant nodules.

Other Diagnostic Studies

Fine needle aspiration cytology

Fine needle aspiration is usually done under ultrasound guidance and the sample is sent for cytology. It helps to differentiate benign thyroid nodules from the malignant lesions.

Gross Pathology

• The gland is usually diffusely enlarged, firm, and slightly lobular. The capsule is intact, and the cut surface is light-tan and has a slight lobular pattern.
• At autopsy, significant subarachnoid hemorrhage from the ruptured berry aneurysm was documented. In addition, the thyroid gland was mildly enlarged and firm. On cut section, the tissue was slightly pale.

Microscopic Pathology

Microscopically, thyroid glands in de Quervain's thyroiditis may show:

• Destruction of the follicular epithelium.
• Loss of the follicular integrity.
• Patchy distribution of non-caseous granulomas.
• Granuloma comprises of colloid, small lymphocytes, neutrophils, and macrophages with or without epithelioid features.