Zollinger-Ellison syndrome causes: Difference between revisions

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| colspan="3" style="background: #4479BA; text-align: center;" | {{fontcolor|#FFF|'''Causes of Hypergastrinemia'''}}
| colspan="3" style="background: #4479BA; text-align: center;" | {{fontcolor|#FFF|'''Causes of Hypergastrinemia'''}}
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! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Appropriate hypergastrinemia}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Appropriate Hypergastrinemia}}
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*Atrophic gastritis with or without pernicious anemia
*Atrophic gastritis with or without pernicious anemia
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*Vagotomy
*Vagotomy
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! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Inappropriate hypergastrinemia}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Inappropriate Hypergastrinemia}}
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*ZES (sporadic or associated with MEN-1)
*ZES (sporadic or associated with MEN-1)

Revision as of 16:55, 3 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Mohamad Alkateb, MBBCh [3]

Overview

The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).

Causes

  • The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
  • Causes of Hypergastrinemia: [2]
Causes of Hypergastrinemia
Appropriate Hypergastrinemia
  • Atrophic gastritis with or without pernicious anemia
  • Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist)
  • Chronic renal failure
  • H pylori pangastritis
  • Vagotomy
Inappropriate Hypergastrinemia
  • ZES (sporadic or associated with MEN-1)
  • Antral-predominant H pylori infection
  • Retained-antrum syndrome
  • Gastric-outlet obstruction
  • Small-bowel resection
Spurious hypergastrinemia
  • Nonfasting patient
  • Inaccurate assay

References

  1. National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
  2. Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin Gastroenterol Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.

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