Thyroid nodule history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

History

• The presence of symptoms
• A change in nodule size
• Previous head or neck radiation exposure
  • Childhood irradiation associated with high risk of malignancy
• Family history
  • Thyroid diseases
  • Thyroid cancer syndromes
  • Endocrine diseases (e.g. multiple endocrine neoplasia type 2 [MEN2], familial adenomatous polyposis, or Cowden syndrome)
• History of neck pain
• a sudden increase in the size of a neck lump
  • Raise the concern of malignancies and hemorrhagic thyroid cysts
• Progressive voice change or hoarseness
  • May be associated with an invasive tumor