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== Thyroid nodule differential diagnosis ==
== Thyroid nodule differential diagnosis ==
In rare cases, a thyroid nodule may reflect one of the hereditary nonmedullary thyroid cancer syndromes such as familial adenomatous polyposis, Werner’s syndrome, Carney complex type 1, or Gardner’s syndrome
In rare cases, a thyroid nodule may reflect one of the hereditary nonmedullary thyroid cancer syndromes such as familial adenomatous polyposis, Werner’s syndrome, Carney complex type 1, or Gardner’s syndrome
{| class="wikitable"
!
!
! colspan="3" |Nodule property
! colspan="3" |Spread
! rowspan="2" |Sudden growth
of neck mass
! colspan="2" |Laboratory
! colspan="2" |Thyroid scintigraphy
!
!
! rowspan="2" |Biopsy result
if indicated
!
|-
!
!
!Fixed
!Mobile
!Painful
!LN
!Vessle
!Metastasis
!TSH
!FT4/T3
!Hot
!Cold
!US finding
!FNA finding
!Associated mutation
|-
|Benign
|Colloid adenoma
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|-
|
|Hashimoto's thyroiditis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|-
|
|Cysts nodules
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|-
|
|Follicular adenomas
|
|
|
|
|
|
|
|↑↑↑
|
|
|
|
|
|
|
* PAX8-PPAR gamma 1 
|-
|
|Hyperplastic nodules
|
|
|
|
|
|
|
|↑↑↑
|
|
|
|
|
|
|
|-
|
|Macrofollicular adenomas
|
|
|
|
|
|
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|↑↑
|
|
|
|
|
|
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|-
|
|Microfollicular or cellular adenomas
|
|
|
|
|
|
|
|↑↑
|
|
|
|
|
|
|
|-
|
|Hürthle cell adenomas
|
|
|
|
|
|
|
|↑↓
|
|
|
|
|
|
|
|-
|Malignant
|Papillary carcinoma
|
|
|
|↑↑↑
|
|
|
|
|
|
|
|
|
|
|
|-
|
|Follicular carcinoma
|
|
|
|
|↑↑↑
|Bone
Lung
|
|↑↓
|
|
|
|
|FLUS
|
* Tumor capsule
* Vascular invasion
|
* ''RAS'' mutations
* PAX8-PPAR gamma 1 
|-
|
|Oxyphilic (Hürthle cell) type carcinoma
|
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|-
|
|Noninvasive follicular thyroid neoplasm 
with papillary-like nuclear features
|
|
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|
|
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|-
|
|Medullary carcinoma
|
|
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|-
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|Anaplastic carcinoma
|
|
|
|
|
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|↑
|
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|-
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|Primary thyroid lymphoma
|
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|-
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|Metastatic carcinoma
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|}


== References ==
== References ==

Revision as of 15:42, 9 August 2017

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Risk calculators and risk factors for Thyroid nodule differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]

Overview

Thyroid nodule differential diagnosis

In rare cases, a thyroid nodule may reflect one of the hereditary nonmedullary thyroid cancer syndromes such as familial adenomatous polyposis, Werner’s syndrome, Carney complex type 1, or Gardner’s syndrome

Nodule property Spread Sudden growth

of neck mass

Laboratory Thyroid scintigraphy Biopsy result

if indicated

Fixed Mobile Painful LN Vessle Metastasis TSH FT4/T3 Hot Cold US finding FNA finding Associated mutation
Benign Colloid adenoma
Hashimoto's thyroiditis
Cysts nodules
Follicular adenomas ↑↑↑
  • PAX8-PPAR gamma 1 
Hyperplastic nodules ↑↑↑
Macrofollicular adenomas ↑↑
Microfollicular or cellular adenomas ↑↑
Hürthle cell adenomas ↑↓
Malignant Papillary carcinoma ↑↑↑
Follicular carcinoma ↑↑↑ Bone

Lung

↑↓ FLUS
  • Tumor capsule
  • Vascular invasion
  • RAS mutations
  • PAX8-PPAR gamma 1 
Oxyphilic (Hürthle cell) type carcinoma
Noninvasive follicular thyroid neoplasm 

with papillary-like nuclear features

Medullary carcinoma
Anaplastic carcinoma ↑
Primary thyroid lymphoma
Metastatic carcinoma

References

Template:WH Template:WS

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