Euthyroid sick syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Causes

• Euthyroid sick syndrome can be caused by any serious illness which predisposes to:
  • Increased level of cytokines
  • Decreased level of leptin
  • Hyper-metabolism
  • Iodine containing contrast medium
  • Decreased protein synthesis
  • Decreased level of thyroid-binding globulin
• The following table summarize the effect of various drugs on thyroid hormones level.

↓ Hormone secretion	↓ T4	↓ TSH	↓ 5' monodeiodinase	↑ Breakdown of thyroid hormones	Thyroid binding globulin
					Increased	Decreased
Lithium Amiodarone	Aluminum hydroxide Ferrous sulphate Sucralfate	Dopamine Octreotide Glucocorticoids	Propylthiouracil Amiodarone Propranolol (high dose)	Phenobarbital Rifampin Phenytoin Carbamazepine	Estrogens Tamoxifen Fluorouracil Methadone Heroin	Androgens Anabolic steroids Glucocorticoids Furosemide Mefenamic acid Salicylates

Causes

Life-threatening Causes

• Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
• [Cause] is a life-threatening cause of [disease].

Common Causes

[Disease name] may be caused by:

• [cause1]
• [cause2]
• [cause3]

• [Disease name] is caused by an infection with [pathogen name].
• [Pathogen name] is caused by [pathogen name].

Less Common Causes

Less common causes of disease name include:

• [cause1]
• [cause2]
• [cause3]

Genetic Causes

• [Disease name] is caused by a mutation in the [gene name] gene.

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

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