Thyroid nodule differential diagnosis: Difference between revisions
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* Pulmonary | |||
* Skeletal metastases | |||
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|multifocal | |multifocal | ||
|unencapsulated and may be partially cystic | |unencapsulated and may be partially cystic | ||
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|FLUS | |FLUS | ||
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|Oxyphilic (Hürthle cell) type carcinoma | |Oxyphilic (Hürthle cell) type carcinoma | ||
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| | |Unifocal | ||
| | May present as multifocal | ||
|hypoechoic, microcalcifications | |||
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Revision as of 20:32, 9 August 2017
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Thyroid nodule Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Thyroid nodule differential diagnosis On the Web |
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American Roentgen Ray Society Images of Thyroid nodule differential diagnosis |
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Risk calculators and risk factors for Thyroid nodule differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
Thyroid nodule differential diagnosis
In rare cases, a thyroid nodule may reflect one of the hereditary nonmedullary thyroid cancer syndromes such as familial adenomatous polyposis, Werner’s syndrome, Carney complex type 1, or Gardner’s syndrome
| Nodule property | Spread | Sudden growth
of neck mass |
Laboratory | Thyroid scintigraphy | Biopsy result
if indicated |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fixed | Mobile | Painful | LN | Vessle | Metastasis | TSH | FT4/T3 | Hot | Cold | US finding | FNA finding | Associated mutation | special consideration | ||||
| Benign | Colloid adenoma | ||||||||||||||||
| Hashimoto's thyroiditis | - | - | + | ||||||||||||||
| Cysts nodules | |||||||||||||||||
| Follicular adenomas | ↑↑↑ |
|
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| Hyperplastic nodules | ↑↑↑ | ||||||||||||||||
| Macrofollicular adenomas | ↑↑ | ||||||||||||||||
| Microfollicular or cellular adenomas | ↑↑ | ||||||||||||||||
| Hürthle cell adenomas | ↑↓ | ||||||||||||||||
| Malignant | Papillary carcinoma | +++ | + | ↑↑↑ | ↑↑↑ |
|
+ | multifocal | unencapsulated and may be partially cystic | papillae consisting of one or two layers of tumor cells surrounding a well-defined fibrovascular core; follicles and colloid are typically absent
The nuclei are large, oval, and appear crowded and overlapping on microscopic sections. They may contain hypodense powdery chromatin, cytoplasmic pseudoinclusions due to a redundant nuclear membrane, or nuclear grooves. |
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| Follicular carcinoma | ↑↑↑ | Bone
Lung |
↑↓ | Unifocal | FLUS |
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Most common thyroid cancer in iodine deficient areas | |||||||||
| Oxyphilic (Hürthle cell) type carcinoma | |||||||||||||||||
| Medullary carcinoma | ↑↑↑ | Unifocal
May present as multifocal |
hypoechoic, microcalcifications | ||||||||||||||
| Anaplastic carcinoma | ↑ | ||||||||||||||||
| Primary thyroid lymphoma | |||||||||||||||||
| Metastatic carcinoma | |||||||||||||||||