Acromegaly natural history, complications and prognosis: Difference between revisions
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===Complications=== | ===Complications=== | ||
*Common complications of acromegaly include: | *Common complications of acromegaly include: | ||
** | **Cardivascualr complications:<ref name="pmid20463098">{{cite journal| author=Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M et al.| title=Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. | journal=J Clin Endocrinol Metab | year= 2010 | volume= 95 | issue= 8 | pages= 3648-56 | pmid=20463098 | doi=10.1210/jc.2009-2570 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20463098 }} </ref> | ||
** [[Cardiovascular disease]] | *** [[Cardiovascular disease]] | ||
** [[ | *** [[Hypertension]] | ||
** [[ | *** [[Arrhythmias]] | ||
** [[ | *** [[Heart failure]] | ||
** [[ | *** Coronary arteriosclerosis | ||
** [[ | **Respiratory complications: | ||
** | ***Sleep apnea | ||
** [[ | ***Dyspnea and stridor | ||
** [[Uterine fibroids]] | **Neuromuscular complications: | ||
***[[Arthritis]] | |||
*** [[Carpal tunnel syndrome]] | |||
*** [[Spinal cord compression]] | |||
*** Vision abnormalities | |||
**Abdominal complications: | |||
*** [[Colonic polyps]] | |||
*** [[Uterine fibroids]] in females | |||
===Prognosis=== | ===Prognosis=== |
Revision as of 21:30, 9 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
- Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- If left untreated, 30% of patients with acromegaly may progress to develop cardiovascular manifestations, pulmonary dysfunction, and cerebral complications. These comorbidities will increase the mortality rate.[1]
Complications
- Common complications of acromegaly include:
- Cardivascualr complications:[2]
- Cardiovascular disease
- Hypertension
- Arrhythmias
- Heart failure
- Coronary arteriosclerosis
- Respiratory complications:
- Sleep apnea
- Dyspnea and stridor
- Neuromuscular complications:
- Arthritis
- Carpal tunnel syndrome
- Spinal cord compression
- Vision abnormalities
- Abdominal complications:
- Colonic polyps
- Uterine fibroids in females
- Cardivascualr complications:[2]
Prognosis
- Prognosis of acromegaly is generally good with transsphenoidal surgery and the postoperative treatment.
- Early diagnosis and treatment of acromegaly is associated with better prognosis.[3]
- The acral features of the acromegaly in the face, hands, and feets usually return to normal after the surgery.
References
- ↑ Melmed S (2009). "Acromegaly pathogenesis and treatment". J Clin Invest. 119 (11): 3189–202. doi:10.1172/JCI39375. PMC 2769196. PMID 19884662.
- ↑ Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M; et al. (2010). "Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control". J Clin Endocrinol Metab. 95 (8): 3648–56. doi:10.1210/jc.2009-2570. PMID 20463098.
- ↑ Kršek M (2015). "[Acromegaly: current view]". Vnitr Lek. 61 (10): 900–4. PMID 26486485.