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*Historical Perspective[ Postpartum ischemic pituitary necrosis was first reported about a century ago in Przeglad Lekarski by Leon Konrad Gliński, though it was named after Harold Sheehan. Postpartum ischemic pituitary necrosis is still one of the most common causes of hypopituitarism in developing countries but it's prevalence is decreased in developed countries because of improved obstetrical care. Mostly, PPH leading to severe hypotension or shock results in Sheehan's syndrome.<ref name="pmid26817341">{{cite journal |vauthors=Krysiak R, Okopień B |title=[Sheehan's syndrome--a forgotten disease with 100 years' history] |language=Polish |journal=Prz. Lek. |volume=72 |issue=6 |pages=313–20 |year=2015 |pmid=26817341 |doi= |url=}}</ref> | *Historical Perspective[ Postpartum ischemic pituitary necrosis was first reported about a century ago in Przeglad Lekarski by Leon Konrad Gliński, though it was named after Harold Sheehan. Postpartum ischemic pituitary necrosis is still one of the most common causes of hypopituitarism in developing countries but it's prevalence is decreased in developed countries because of improved obstetrical care. Mostly, PPH leading to severe hypotension or shock results in Sheehan's syndrome.<ref name="pmid26817341">{{cite journal |vauthors=Krysiak R, Okopień B |title=[Sheehan's syndrome--a forgotten disease with 100 years' history] |language=Polish |journal=Prz. Lek. |volume=72 |issue=6 |pages=313–20 |year=2015 |pmid=26817341 |doi= |url=}}</ref> | ||
*Classification[edit | edit source] | *Classification[edit | edit source] | ||
*Pathophysiology[Apart from vasospasm, thrombosis and compression of the hypophyseal arteries, | *Pathophysiology[Apart from vasospasm, thrombosis and compression of the hypophyseal arteries, pituitary gland enlargement, autoimmunity, DIC and smaller size of sella are thought to play a contributing role in pathogenesis of sheehan Syndrome.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi= |url=}}</ref>. It is thought that tissue necrosis could release sequestered antigens, potentiaiting autoimmunity of the pituitary and hypopituitarism in Sheehan's syndrome.<ref name="pmid12213861">{{cite journal |vauthors=Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N |title=Pituitary autoimmunity in patients with Sheehan's syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue=9 |pages=4137–41 |year=2002 |pmid=12213861 |doi=10.1210/jc.2001-020242 |url=}}</ref> ] | ||
*Causes[edit | edit source] | *Causes[edit | edit source] | ||
Differentiating ((Page name)) from Other Diseases[edit | edit source] | Differentiating ((Page name)) from Other Diseases[edit | edit source] | ||
Revision as of 16:07, 10 August 2017
- Historical Perspective[ Postpartum ischemic pituitary necrosis was first reported about a century ago in Przeglad Lekarski by Leon Konrad Gliński, though it was named after Harold Sheehan. Postpartum ischemic pituitary necrosis is still one of the most common causes of hypopituitarism in developing countries but it's prevalence is decreased in developed countries because of improved obstetrical care. Mostly, PPH leading to severe hypotension or shock results in Sheehan's syndrome.[1]
- Classification[edit | edit source]
- Pathophysiology[Apart from vasospasm, thrombosis and compression of the hypophyseal arteries, pituitary gland enlargement, autoimmunity, DIC and smaller size of sella are thought to play a contributing role in pathogenesis of sheehan Syndrome.[2]. It is thought that tissue necrosis could release sequestered antigens, potentiaiting autoimmunity of the pituitary and hypopituitarism in Sheehan's syndrome.[3] ]
- Causes[edit | edit source]
Differentiating ((Page name)) from Other Diseases[edit | edit source]
- Epidemiology and Demographics: [ ]
- Risk Factors[edit | edit source]
- Screening[edit | edit source]
- Natural History, Complications, and Prognosis[edit | edit source]
- Diagnosis[edit | edit source]
- Diagnostic Criteria[edit | edit source]
History and Symptoms[edit | edit source] Physical Examination[edit | edit source] Laboratory Findings[edit | edit source] Electrocardiogram[edit | edit source] X-ray[edit | edit source] CT scan[edit | edit source] MRI[edit | edit source] Ultrasound[edit | edit source] Other Imaging Findings[edit | edit source] Other Diagnostic Studies[edit | edit source] Treatment[edit | edit source] Medical Therapy[edit | edit source] Surgery[edit | edit source] Primary Prevention[edit | edit source] Secondary Prevention[edit | edit source] References[edit | edit source]
- ↑ Krysiak R, Okopień B (2015). "[Sheehan's syndrome--a forgotten disease with 100 years' history]". Prz. Lek. (in Polish). 72 (6): 313–20. PMID 26817341.
- ↑ Keleştimur F (2003). "Sheehan's syndrome". Pituitary. 6 (4): 181–8. PMID 15237929.
- ↑ Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N (2002). "Pituitary autoimmunity in patients with Sheehan's syndrome". J. Clin. Endocrinol. Metab. 87 (9): 4137–41. doi:10.1210/jc.2001-020242. PMID 12213861.