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== Overview==


==Pathophysiology==
==Pathophysiology==
Various theories have been implicated in the pathogenesis of anxiety  which are as follows:
* Biologic component:
**There is an increased sympathetic tone
** There is a surge of catecholamines
**Decreased levels of Gamma -aminobutyric acid(GABA)
**Alterations in serotonergic and dopaminergic system
** In anxiety states like panic attacks, the locus ceruleus is hyperactive
** Hyperactivity of amygdala has been implicated in social anxiety
* Psychoanalytic component:
* Freud described that anxiety is developmentally related to childhood fears of disintegration that derive from the fear of actual or imagined loss of a love object or fear of bodily harm.
** He used the term "signal anxiety" to describe anxiety that triggers defense mechanisms used by the person to cope with the potential threat, but anxiety infact, is not consciously experienced.
* learning theory
** Anxiety is produced due to continued stress.
** The anxiety eventually becomes a conditioned response to stress ful situations of less severity
* Genetic studies
** ABout 5% individuals with anxiety have polymorphic variant of the gene associated with serotonin transporter metabolism.
**Hyperactivity of amygdala has been implicated in social anxiety.


==References==
==References==

Revision as of 17:24, 16 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Template:AeVindhya BellamKonda, M.B.B.S [2]

Overview

Pathophysiology

Various theories have been implicated in the pathogenesis of anxiety which are as follows:

  • Biologic component:
    • There is an increased sympathetic tone
    • There is a surge of catecholamines
    • Decreased levels of Gamma -aminobutyric acid(GABA)
    • Alterations in serotonergic and dopaminergic system
    • In anxiety states like panic attacks, the locus ceruleus is hyperactive
    • Hyperactivity of amygdala has been implicated in social anxiety
  • Psychoanalytic component:
  • Freud described that anxiety is developmentally related to childhood fears of disintegration that derive from the fear of actual or imagined loss of a love object or fear of bodily harm.
    • He used the term "signal anxiety" to describe anxiety that triggers defense mechanisms used by the person to cope with the potential threat, but anxiety infact, is not consciously experienced.
  • learning theory
    • Anxiety is produced due to continued stress.
    • The anxiety eventually becomes a conditioned response to stress ful situations of less severity
  • Genetic studies
    • ABout 5% individuals with anxiety have polymorphic variant of the gene associated with serotonin transporter metabolism.
    • Hyperactivity of amygdala has been implicated in social anxiety.

References

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