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** Hyperactivity of amygdala has been implicated in social anxiety
** Hyperactivity of amygdala has been implicated in social anxiety
* Psychoanalytic component:
* Psychoanalytic component:
* Freud described that anxiety is developmentally related to childhood fears of disintegration that derive from the fear of actual or imagined loss of a love object or fear of bodily harm.
** Freud described that anxiety is developmentally related to childhood fears of disintegration that derive from the fear of actual or imagined loss of a love object or fear of bodily harm.
** He used the term "signal anxiety" to describe anxiety that triggers defense mechanisms used by the person to cope with the potential threat, but anxiety infact, is not consciously experienced.
** He used the term "signal anxiety" to describe anxiety that triggers defense mechanisms used by the person to cope with the potential threat, but anxiety infact, is not consciously experienced.


Line 25: Line 25:
** The anxiety eventually becomes a conditioned response to stress ful situations of less severity
** The anxiety eventually becomes a conditioned response to stress ful situations of less severity
* Genetic studies
* Genetic studies
** ABout 5% individuals with anxiety have polymorphic variant of the gene associated with serotonin transporter metabolism.
** About 5% individuals with anxiety have polymorphic variant of the gene associated with serotonin transporter metabolism.
 
**Hyperactivity of amygdala has been implicated in social anxiety.


==References==
==References==

Revision as of 17:25, 16 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Template:AeVindhya BellamKonda, M.B.B.S [2]

Overview

Pathophysiology

Various theories have been implicated in the pathogenesis of anxiety which are as follows:

  • Biologic component:
    • There is an increased sympathetic tone
    • There is a surge of catecholamines
    • Decreased levels of Gamma -aminobutyric acid(GABA)
    • Alterations in serotonergic and dopaminergic system
    • In anxiety states like panic attacks, the locus ceruleus is hyperactive
    • Hyperactivity of amygdala has been implicated in social anxiety
  • Psychoanalytic component:
    • Freud described that anxiety is developmentally related to childhood fears of disintegration that derive from the fear of actual or imagined loss of a love object or fear of bodily harm.
    • He used the term "signal anxiety" to describe anxiety that triggers defense mechanisms used by the person to cope with the potential threat, but anxiety infact, is not consciously experienced.
  • learning theory
    • Anxiety is produced due to continued stress.
    • The anxiety eventually becomes a conditioned response to stress ful situations of less severity
  • Genetic studies
    • About 5% individuals with anxiety have polymorphic variant of the gene associated with serotonin transporter metabolism.

References

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