Hypoglycemia pathophysiology: Difference between revisions
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== Genetics == | == Genetics == | ||
Genes associated with Diabetes mellitus include the following: | *Genes associated with Diabetes mellitus include the following: | ||
* Currently, 58 [[Genomics|genomic regions]] are found to be associated with Type 1 DM. | **Currently, 58 [[Genomics|genomic regions]] are found to be associated with Type 1 DM. | ||
**Major susceptibility gene for type 1 DM is located on [[HLA]] region of [[Chromosome 6 (human)|chromosome 6]]. It accounts for 40-50% of the genetic risk for type 1 DM. This region encodes for class II [[major histocompatibility complex]] (MHC) molecules. Class II major histocompatibility complex (MHC) molecules play an important role in presenting antigen to helper [[T cell|T cells]] and initiating immune response. | |||
* Major susceptibility gene for type 1 DM is located on [[HLA]] region of [[Chromosome 6 (human)|chromosome 6]]. It accounts for 40-50% of the genetic risk for type 1 DM. This region encodes for class II [[major histocompatibility complex]] (MHC) molecules. Class II major histocompatibility complex (MHC) molecules play an important role in presenting antigen to helper [[T cell|T cells]] and initiating immune response. | **Other major susceptibility genes which were associated with Type 1 DM include [[polymorphisms]] in the [[promoter region]] of the insulin gene, the CTLA-4 gene, [[IL-2|interleukin 2 receptor]], CTLA4, and PTPN22 etc | ||
**Presence of certain genes confer protection against the development of the disease. Haplotype DQA1*0102, DQB1*0602 is extremely rare in individuals with type 1 DM (<1%) and appears to provide protection from type 1 DM. | |||
* Other major susceptibility genes which were associated with Type 1 DM include [[polymorphisms]] in the [[promoter region]] of the insulin gene, the CTLA-4 gene, [[IL-2|interleukin 2 receptor]], CTLA4, and PTPN22 etc | *Genetics associated with Bechwith-wiedmann syndrome:<ref name="pmid16010676">{{cite journal| author=Weksberg R, Shuman C, Smith AC| title=Beckwith-Wiedemann syndrome. | journal=Am J Med Genet C Semin Med Genet | year= 2005 | volume= 137C | issue= 1 | pages= 12-23 | pmid=16010676 | doi=10.1002/ajmg.c.30058 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16010676 }}</ref> | ||
* Presence of certain genes confer protection against the development of the disease. Haplotype DQA1*0102, DQB1*0602 is extremely rare in individuals with type 1 DM (<1%) and appears to provide protection from type 1 DM. | **Deregulation of imprinted gene expression in the chromosome 11p15.5 region can result in the BWS phenotype]. | ||
* Genetics associated with Bechwith-wiedmann syndrome:<ref name="pmid16010676">{{cite journal| author=Weksberg R, Shuman C, Smith AC| title=Beckwith-Wiedemann syndrome. | journal=Am J Med Genet C Semin Med Genet | year= 2005 | volume= 137C | issue= 1 | pages= 12-23 | pmid=16010676 | doi=10.1002/ajmg.c.30058 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16010676 }}</ref> | **The critical BWS genes in that region include insulin-like growth factor 2 (''IGF2''), ''H19'', cyclin-dependent kinase inhibitor 1C (''CDKN1C''), potassium channel voltage-gated KQT-like subfamily member 1 (''KCNQ1''), and ''KCNQ1''-overlapping transcript 1 (''KCNQ1OT1'', or long QT intronic transcript 1). | ||
*Autoimmune hypoglycemia genetics:<ref name="pmid11182636">{{cite journal| author=Murakami M, Mizuide M, Kashima K, Kojima A, Tomioka SI, Kohama T et al.| title=Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. | journal=Horm Res | year= 2000 | volume= 54 | issue= 1 | pages= 49-52 | pmid=11182636 | doi=63437 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11182636 }}</ref> | |||
* Deregulation of imprinted gene expression in the chromosome 11p15.5 region can result in the BWS phenotype]. | **Serological HLA typing demonstrated the patient had HLA-DR4. | ||
* The critical BWS genes in that region include insulin-like growth factor 2 (''IGF2''), ''H19'', cyclin-dependent kinase inhibitor 1C (''CDKN1C''), potassium channel voltage-gated KQT-like subfamily member 1 (''KCNQ1''), and ''KCNQ1''-overlapping transcript 1 (''KCNQ1OT1'', or long QT intronic transcript 1). | **DNA typing showed she had HLA-DRB1*0401 and HLA-DRB1*0406 is strikingly associated with patients with insulin autoimmune syndrome who have polyclonal insulin autoantibodies. | ||
* Autoimmune hypoglycemia genetics:<ref name="pmid11182636">{{cite journal| author=Murakami M, Mizuide M, Kashima K, Kojima A, Tomioka SI, Kohama T et al.| title=Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401. | journal=Horm Res | year= 2000 | volume= 54 | issue= 1 | pages= 49-52 | pmid=11182636 | doi=63437 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11182636 }}</ref> | |||
* Serological HLA typing demonstrated the patient had HLA-DR4. | |||
* DNA typing showed she had HLA-DRB1*0401 and HLA-DRB1*0406 is strikingly associated with patients with insulin autoimmune syndrome who have polyclonal insulin autoantibodies. | |||
== Gross pathology == | == Gross pathology == | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
The pathophysiology of hypoglycemia depends on the failure of physiological defense mechanisms and hormones such as insulin, glucagon and epinephrine to correct hypoglycemia. Most of these defense mechanisms are hormones that control glycogenolysis and gluconeogenesis.
Pathogenesis
The pathophysiology of hypoglycemia depends on the failure of physiological defense mechanisms and hormones such as insulin, glucagon and epinephrine to correct hypoglycemia. Most of these defense mechanisms are hormones that control glycogenolysis and gluconeogenesis as follows:
The most important and the first mechanism to counter-regulate hypoglycemia is the ability to suppress insulin release. This happens early when blood glucose level is in-between 80–85 mmHg. This cannot occur in patients with absolute beta-cell failure as patients with type 1 diabetes and long-standing type 2 diabetes.[1]High insulin level inhibits hepatic glycogenolysis causing more hypoglycemia.
Hypoglycemia stimulates secretion of glucagon. This happens when blood glucose level falls in-between 65–70 mmHg. Failure to secrete glucagon may be the result of beta-cell failure and high insulin level that inhibits glucagon secretion.[2]
Epinephrine response to hypoglycemia also becomes suppressed in many patients.[3] This happens when blood glucose level falls in-between 65–70mmHg. A suppressed epinephrine response causes defective glucose counter-regulation and hypoglycemia unawareness.[4] This may be due to shifting the glycemic threshold for the sympathoadrenal response to a lower plasma glucose concentration.
The brain is the first organ to be affected by decreased blood glucose level. Impairment of judgment and Seizures may occur resulting in coma.
Genetics
- Genes associated with Diabetes mellitus include the following:
- Currently, 58 genomic regions are found to be associated with Type 1 DM.
- Major susceptibility gene for type 1 DM is located on HLA region of chromosome 6. It accounts for 40-50% of the genetic risk for type 1 DM. This region encodes for class II major histocompatibility complex (MHC) molecules. Class II major histocompatibility complex (MHC) molecules play an important role in presenting antigen to helper T cells and initiating immune response.
- Other major susceptibility genes which were associated with Type 1 DM include polymorphisms in the promoter region of the insulin gene, the CTLA-4 gene, interleukin 2 receptor, CTLA4, and PTPN22 etc
- Presence of certain genes confer protection against the development of the disease. Haplotype DQA1*0102, DQB1*0602 is extremely rare in individuals with type 1 DM (<1%) and appears to provide protection from type 1 DM.
- Genetics associated with Bechwith-wiedmann syndrome:[5]
- Deregulation of imprinted gene expression in the chromosome 11p15.5 region can result in the BWS phenotype].
- The critical BWS genes in that region include insulin-like growth factor 2 (IGF2), H19, cyclin-dependent kinase inhibitor 1C (CDKN1C), potassium channel voltage-gated KQT-like subfamily member 1 (KCNQ1), and KCNQ1-overlapping transcript 1 (KCNQ1OT1, or long QT intronic transcript 1).
- Autoimmune hypoglycemia genetics:[6]
- Serological HLA typing demonstrated the patient had HLA-DR4.
- DNA typing showed she had HLA-DRB1*0401 and HLA-DRB1*0406 is strikingly associated with patients with insulin autoimmune syndrome who have polyclonal insulin autoantibodies.
Gross pathology
On gross pathology insulinomas have a gray to red brown appearance, encapsulated [12]and are usually small and solitary tumors. Although there is a case report of a large(9cm), pedunculated and weighing more than 100g.[7]
- Almost all insulinomas are present throughout the pancreas and extrapancreatic ones causing hypoglycemia are rare(<2%).[8]
- Various other findings are noted on gross pathology such as:[9]
- Size of the tumor
- Metastasis to lymph nodes
- Extrapancreatic involvement
- Distant metastasis
Microscopic pathology
On microscopic histopathological analysis,patterns like trabecular, gyriform, lobular and solid structures particularly with amyloid in fibrovascular stroma are characteristic findings of insulinoma..[10] It is also evaluated for the mitotic index(mitosis per 10 high power field) and immunohistochemistry staining by Chromogranin A, synaptophysin, and Ki-67 index.[11] The structure of tumor cells observed under electron microscopy as: Group A characterised by abundant well-granulated typical B cells with trabecular arrangement and Group B as scarce well -granulated typical B cells and a medullary arrangement.
References
- ↑ Dunning BE, Gerich JE (2007). "The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications". Endocr Rev. 28 (3): 253–83. doi:10.1210/er.2006-0026. PMID 17409288.
- ↑ Raju B, Cryer PE (2005). "Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans". Diabetes. 54 (3): 757–64. PMID 15734853.
- ↑ Dagogo-Jack SE, Craft S, Cryer PE (1993). "Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia". J Clin Invest. 91 (3): 819–28. doi:10.1172/JCI116302. PMC 288033. PMID 8450063.
- ↑ Geddes J, Schopman JE, Zammitt NN, Frier BM (2008). "Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes". Diabet Med. 25 (4): 501–4. doi:10.1111/j.1464-5491.2008.02413.x. PMID 18387080.
- ↑ Weksberg R, Shuman C, Smith AC (2005). "Beckwith-Wiedemann syndrome". Am J Med Genet C Semin Med Genet. 137C (1): 12–23. doi:10.1002/ajmg.c.30058. PMID 16010676.
- ↑ Murakami M, Mizuide M, Kashima K, Kojima A, Tomioka SI, Kohama T; et al. (2000). "Identification of monoclonal insulin autoantibodies in insulin autoimmune syndrome associated with HLA-DRB1*0401". Horm Res. 54 (1): 49–52. doi:63437 Check
|doi=value (help). PMID 11182636. - ↑ Mittendorf EA, Liu YC, McHenry CR (2005). "Giant insulinoma: case report and review of the literature". J Clin Endocrinol Metab. 90 (1): 575–80. doi:10.1210/jc.2004-0825. PMID 15522939.
- ↑ Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y; et al. (2013). "Diagnosis and management of insulinoma". World J Gastroenterol. 19 (6): 829–37. doi:10.3748/wjg.v19.i6.829. PMC 3574879. PMID 23430217.
- ↑ de Herder WW, Niederle B, Scoazec JY, Pauwels S, Kloppel G, Falconi M; et al. (2006). "Well-differentiated pancreatic tumor/carcinoma: insulinoma". Neuroendocrinology. 84 (3): 183–8. doi:10.1159/000098010. PMID 17312378.
- ↑ Lloyd, Ricardo (2010). Endocrine pathology : differential diagnosis and molecular advances. New York London: Springer. ISBN 978-1441910684.
- ↑ de Herder, Wouter W.; Niederle, Bruno; Scoazec, Jean-Yves; Pauwels, Stanislas; Klöppel, Günter; Falconi, Massimo; Kwekkeboom, Dik J.; Öberg, Kjel; Eriksson, Barbro; Wiedenmann, Bertram; Rindi, Guido; O’Toole, Dermot; Ferone, Diego (2007). "Well-Differentiated Pancreatic Tumor/Carcinoma: Insulinoma". Neuroendocrinology. 84 (3): 183–188. doi:10.1159/000098010. ISSN 0028-3835.