Pheochromocytoma epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The [[incidence]] of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to | The [[incidence]] of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to as high as 0.8 per 100,000 persons. The average age at diagnosis is 24.9 years in familial cases and 43.9 years in sporadic cases. Both men and women are affected equally by pheochromocytoma. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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* In the USA, the [[incidence]] of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to a high of 0.8 per 100,000 persons.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc</ref>. | * In the USA, the [[incidence]] of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to a high of 0.8 per 100,000 persons.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc</ref>. | ||
* Annually reported cases range from 500 to 1600 in the United States.<ref name="pmid20664475">{{cite journal| author=Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K et al.| title=The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. | journal=Pancreas | year= 2010 | volume= 39 | issue= 6 | pages= 775-83 | pmid=20664475 | doi=10.1097/MPA.0b013e3181ebb4f0 | pmc=3419007 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20664475 }}</ref> | * Annually reported cases range from 500 to 1600 in the United States.<ref name="pmid20664475">{{cite journal| author=Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K et al.| title=The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. | journal=Pancreas | year= 2010 | volume= 39 | issue= 6 | pages= 775-83 | pmid=20664475 | doi=10.1097/MPA.0b013e3181ebb4f0 | pmc=3419007 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20664475 }}</ref> | ||
* [[Autopsy]] studies have discovered a higher number of cases than the actual [[prevalence]] rates. | * [[Autopsy]] studies have discovered a higher number of cases than the actual [[prevalence]] rates. Ten percent of pheochromocytomas cases are discovered by chance. | ||
=== Prevalence === | === Prevalence === | ||
* The prevalence of | * The [[prevalence]] of pheochromocytoma in patients with [[hypertension]] in general outpatient clinics varies between 0.2 and 0.6%. | ||
* | * The prevalence of pheochromocytoma is approximately 1.7% in children with hypertension. | ||
* | * About 5% of patients with incidentally discovered adrenal masses on imaging actually have pheochromocytoma. | ||
* The prevalence of | * The prevalence of pheochromocytoma in individuals carrying a germline mutation in pheochromocytoma susceptibility genes may be around 50%. | ||
* Patients with hereditary | * Patients with hereditary pheochromocytoma typically present with multifocal disease and at a younger age than those with sporadic neoplasms. | ||
=== Age === | === Age === | ||
| Line 28: | Line 28: | ||
===Gender=== | ===Gender=== | ||
* | * Both men and women are affected equally by pheochromocytoma.<ref name="cancergov" /> | ||
==References== | ==References== | ||
Revision as of 15:06, 12 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Mohammed Abdelwahed M.D[3]
Overview
The incidence of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to as high as 0.8 per 100,000 persons. The average age at diagnosis is 24.9 years in familial cases and 43.9 years in sporadic cases. Both men and women are affected equally by pheochromocytoma.
Epidemiology and Demographics
Incidence
- In the USA, the incidence of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to a high of 0.8 per 100,000 persons.[1].
- Annually reported cases range from 500 to 1600 in the United States.[2]
- Autopsy studies have discovered a higher number of cases than the actual prevalence rates. Ten percent of pheochromocytomas cases are discovered by chance.
Prevalence
- The prevalence of pheochromocytoma in patients with hypertension in general outpatient clinics varies between 0.2 and 0.6%.
- The prevalence of pheochromocytoma is approximately 1.7% in children with hypertension.
- About 5% of patients with incidentally discovered adrenal masses on imaging actually have pheochromocytoma.
- The prevalence of pheochromocytoma in individuals carrying a germline mutation in pheochromocytoma susceptibility genes may be around 50%.
- Patients with hereditary pheochromocytoma typically present with multifocal disease and at a younger age than those with sporadic neoplasms.
Age
- The peak incidence of pheochromocytoma occurs in third decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.[1]
- Hereditary tumors present at a younger age than sporadic.
- Approximately 10% occur in children.
Race
- Pheochromocytomas occur across all races but is found less commonly in blacks.
Gender
- Both men and women are affected equally by pheochromocytoma.[1]
References
- ↑ 1.0 1.1 1.2 National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc
- ↑ Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K; et al. (2010). "The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer". Pancreas. 39 (6): 775–83. doi:10.1097/MPA.0b013e3181ebb4f0. PMC 3419007. PMID 20664475.