Hypopituitarism laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Laboratory Findings

Electrolyte and Biomarker Studies

Hormonal deficiency	Lab finding
ACTH	Hypoglycemia Eosinophilia
TSH
Gonadotropins
GH
Prolactin
ADH
Oxytocin

ACTH stimulation test: The ACTH stimulation test is the most common test for patients who are suspected of diagnosing adrenal insufficiency. During this test, before and after being injected ACTH, the patient is detected with the level of blood cortisol and urine cortisol. In normal person, after an ACTH injection, it may show a rise in blood and urine cortisol levels. Patients with causes of adrenal insufficiency have little or no increase in cortisol levels.

• CRH stimulation test: This test can differ the primary and secondary adrenal insufficiency. In this test, the patient is injected synthetic CRH and measured blood cortisol before and 30, 60, 90, and 120 minutes after the injection. The leval of blood cortisol in people with primary adrenal insufficiency such as Addison’s disease, demonatrates high levels of ACTH but no cortisol. For the patients with secondary adrenal insufficiency, they appear absent or delayed ACTH.
• Triple bolus test: A provocative test measures the secretory response of the pituitary to a stimulus (other hormones, drugs, exercise, etc.) by measuring serum levels of the hormone involved.

Overview

• An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
• Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
• [Test] is usually normal among patients with [disease name].
• Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

• There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

• There are no diagnostic laboratory findings associated with [disease name].

OR

• An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
• [Test] is usually normal among patients with [disease name].
• Laboratory findings consistent with the diagnosis of [disease name] include
  • [abnormal test 1]
  • [abnormal test 2]
  • [abnormal test 3]

• Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].