Zollinger-Ellison syndrome classification: Difference between revisions
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|Neuroendocrine carcinoma | |Neuroendocrine carcinoma | ||
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*The following table illustrates the factors associated and the differences between | *The following table illustrates the factors associated and the differences between sporadic and [[MEN-1]]-associated ZES: <ref name="pmid24319020">{{cite journal |vauthors=Epelboym I, Mazeh H |title=Zollinger-Ellison syndrome: classical considerations and current controversies |journal=Oncologist |volume=19 |issue=1 |pages=44–50 |year=2014 |pmid=24319020 |pmc=3903066 |doi=10.1634/theoncologist.2013-0369 |url=}}</ref> | ||
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*Family History | *Family History | ||
*Other Endocrinopathies | *Other Endocrinopathies | ||
*Gastrinoma Size | *[[Gastrinoma]] Size | ||
*Number of tumors | *Number of tumors | ||
* Most | *Most common tumor location | ||
*Lymph | *[[Lymph node]] primary | ||
*Surgical | *Surgical cure rate | ||
*Malignant | *Malignant potential | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*80% | *80% | ||
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*>2cm | *>2cm | ||
*Single | *Single | ||
*Pancreas | *[[Pancreas]] | ||
*10% | *10% | ||
*60% | *60% | ||
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*<2cm | *<2cm | ||
*Multiple | *Multiple | ||
*Duodenum | *[[Duodenum]] | ||
*No | *No | ||
*Rare | *Rare |
Revision as of 15:54, 11 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
- According to the World Health Organization, neuroendocrine tumors (NETs) are classified into two broad categories namely, well differentiated and poorly differentiated. On the basis of histopathological analysis, most gastrinomas are considered well-differentiated neuroendocrine tumors (NETs).
Classiffication
- Gastrinomas are generally classified under the larger entity, "neuroendocrine tumors" (NETs).
- Among the enteroendocrine cells that arise from the embryologic endoderm, the gastrinomas are derived mainly from the pancreas, and also from the proximal small intestine. [1]
- According to the World Health Organization, neuroendocrine tumors (NETs) are classified into two broad categories; well differentiated, and poorly differentiated gastrinomas. On the basis of histopathological analysis, most of the gastrinomas are considered well-differentiated neuroendocrine tumors (NETs). [2]
- The WHO (2010) classified all neuroendocrine tumors, including gastrinomas into three grades based on the mitotic rate, or Ki-67 index: [3]
Grade Diffrentiation Mitotic range Ki-67 index Behavior WHO category G1 Low grade well-differentiated < 2 < 3% (10% to 30%) Uncertain Neuroendocrine tumor G2 Intermediate grade, well-differentiated 2 to 20 3% to 20% (50% to 80%) Low-grade malignant Neuroendocrine tumor G3 High grade, poorly differentiated > 20 > 20% (1% to 3%) High-grade malignant Neuroendocrine carcinoma
- The following table illustrates the factors associated and the differences between sporadic and MEN-1-associated ZES: [4]
Sporadic and MEN-1-associated ZES | ||
Factors | Sopradic ZES | MEN-1 ZES |
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|
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References
- ↑ Norton JA (1994). "Neuroendocrine tumors of the pancreas and duodenum". Curr Probl Surg. 31 (2): 77–156. PMID 7904550.
- ↑ O'Toole D, Delle Fave G, Jensen RT (2012). "Gastric and duodenal neuroendocrine tumours". Best Pract Res Clin Gastroenterol. 26 (6): 719–35. doi:10.1016/j.bpg.2013.01.002. PMID 23582915.
- ↑ "Gastrinoma - StatPearls - NCBI Bookshelf".
- ↑ Epelboym I, Mazeh H (2014). "Zollinger-Ellison syndrome: classical considerations and current controversies". Oncologist. 19 (1): 44–50. doi:10.1634/theoncologist.2013-0369. PMC 3903066. PMID 24319020.