Celiac disease classification: Difference between revisions
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{{CMG}}; {{AE}} | {{CMG}}; {{AE}} | ||
==Overview== | ==Overview== | ||
Celiac disease (CD) may be classified according to the burden of symptoms and laboratory findings into 5 sub groups as, classical, atypical, asymptomatic, latent, and potential CD. | |||
==Classification== | ==Classification== | ||
Celiac disease (CD) may be classified according to burden of symptoms into five sub groups: | |||
*Classical | |||
*Atypical | |||
*Asymptomatic | |||
** | *Latent | ||
** | *Potential CD | ||
* | {| class="wikitable" | ||
!Type | |||
!Characteristics | |||
|- | |||
|Classical | |||
|Classic CD has typical feature of [[gastrointestinal]] symptoms and signs (eg, [[chronic diarrhea]]) and extraintestinal symptoms and signs (eg, [[Anemia|anaemia]], [[neuropathy]], [[decreased bone density]], increased risk of [[fractures]]) | |||
|- | |||
|Atypical | |||
|Atypical CD presents with minor [[gastrointestinal]] symptoms and signs and is associated with some rare manifestations, such as [[anemia]], dental enamel defects, [[osteoporosis]], [[arthritis]], increased [[transaminases]], neurological symptoms, or [[infertility]]. | |||
|- | |||
|Asymptomatic | |||
|Silent CD is defined as the presence of positive CD-specific [[antibodies]], [[HLA]], and small-bowel biopsy findings that are compatible with CD but without sufficient symptoms and signs to warrant clinical suspicion of CD. | |||
|- | |||
|Latent | |||
|Latent CD is defined by the presence of compatible [[HLA]] but without enteropathy in a patient who has had a [[gluten]]-dependent [[enteropathy]] at some point in his or her life. The patient may or may not have symptoms and may or may not have CD-specific [[antibodies]]. | |||
|- | |||
|Potential CD | |||
|Potential CD is defined by the presence of CD-specific [[antibodies]] and compatible [[HLA]] but without histological abnormalities in [[duodenal]] biopsies. The patient may or may not have symptoms and signs and may or may not develop a gluten dependent [[enteropathy]] later. | |||
|} | |||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Disease]] | [[Category:Disease]] |
Revision as of 18:06, 12 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Celiac disease (CD) may be classified according to the burden of symptoms and laboratory findings into 5 sub groups as, classical, atypical, asymptomatic, latent, and potential CD.
Classification
Celiac disease (CD) may be classified according to burden of symptoms into five sub groups:
- Classical
- Atypical
- Asymptomatic
- Latent
- Potential CD
Type | Characteristics |
---|---|
Classical | Classic CD has typical feature of gastrointestinal symptoms and signs (eg, chronic diarrhea) and extraintestinal symptoms and signs (eg, anaemia, neuropathy, decreased bone density, increased risk of fractures) |
Atypical | Atypical CD presents with minor gastrointestinal symptoms and signs and is associated with some rare manifestations, such as anemia, dental enamel defects, osteoporosis, arthritis, increased transaminases, neurological symptoms, or infertility. |
Asymptomatic | Silent CD is defined as the presence of positive CD-specific antibodies, HLA, and small-bowel biopsy findings that are compatible with CD but without sufficient symptoms and signs to warrant clinical suspicion of CD. |
Latent | Latent CD is defined by the presence of compatible HLA but without enteropathy in a patient who has had a gluten-dependent enteropathy at some point in his or her life. The patient may or may not have symptoms and may or may not have CD-specific antibodies. |
Potential CD | Potential CD is defined by the presence of CD-specific antibodies and compatible HLA but without histological abnormalities in duodenal biopsies. The patient may or may not have symptoms and signs and may or may not develop a gluten dependent enteropathy later. |