Adrenocortical carcinoma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

Some patients with adrenocortical carcinoma may have elevated concentration of serum cortisol, aldosterone, testosterone or estrogen and reduced concentration of plasma renin and potassium.

Laboratory Findings

Laboratory findings that may associate adrenocortical carcinoma are:

Hormonal disturbance	labs
Cortisol	Cortisol level ACTH (10 pg/mL) 24-hour urinary free cortisol Fasting serum cortisol at 8 AM following a 1 mg dose of dexamethasone at bedtime
Steroids [85]	Adrenal androgens [DHEAS] Androstenedione Bioavailable testosterone should be measured in every patient. 17-hydroxyprogesterone Serum estradiol in men and postmenopausal women A recent study has shown significant differences in steroid hormone precursor and metabolite profiles in urine of patients with ACC compared with patients with benign adrenal tumors (95)
Epinephrine (96)	Metanephrine and normetanephrine in plasma or 24-hour urine
Aldosterone [86,87]	Low serum aldosterone concentrations, normal or high serum or urinary concentrations of aldosterone precursors