Adrenocortical carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]

Overview

Adrenocortical carcinoma is classified according to hormone production and histological appearance. ACC may secrete Cortisol, Aldosterone, Testosterone, Estrogen. Other variants include oncocytic adrenal cortical carcinoma, myxoid adrenal cortical carcinoma, and carcinosarcoma.

Classification

Adrenocortical carcinomas are classified depending on:

Hormones production

• Functional, produce one or more of the followings hormones:
• Cortisol
• Aldosterone
• Testosterone
• Estrogen

• Nonfunctional

Histology

• Well differentiated
• Intermediate differentiated
• Poorly differentiated
• Anaplastic

Variants

• Oncocytic adrenal cortical carcinoma
• Myxoid adrenal cortical carcinoma
• Carcinosarcoma
• Adenosquamous adrenocortical carcinoma
• Clear cell adrenal cortical carcinoma