Adrenocortical carcinoma history and symptoms: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Iqra Qamar (talk | contribs) |
||
| Line 3: | Line 3: | ||
{{CMG}}; {{AE}} {{RT}} {{AAM}} {{MAD}} | {{CMG}}; {{AE}} {{RT}} {{AAM}} {{MAD}} | ||
==Overview== | ==Overview== | ||
Symptoms of [[adrenocortical carcinoma]] include symptoms of [[androgen]], [[glucocorticoid]], [[mineralocorticoid]], or [[estrogen]] excess. Symptoms of [[glucocorticoid]] excess include [[Weight gain]], [[Acne]], irritability. Symptoms of [[androgen]] excess | Symptoms of [[adrenocortical carcinoma]] include symptoms of [[androgen]], [[glucocorticoid]], [[mineralocorticoid]], or [[estrogen]] excess. Symptoms of [[glucocorticoid]] excess include [[Weight gain]], [[Acne]], irritability. Symptoms of [[androgen]] excess include [[hirsuitism|hirsutism]], [[Irritability|acne]], and [[Irritability|deepening of the voice.]] Symptoms [[Irritability|of]] [[mineralcorticoid|mineralocorticoid]] excess include [[headache]], [[Muscle weakness|muscle weakness,]] [[Confusion]], and [[Palpitations|palpitations.]] | ||
==Common Symptoms== | ==Common Symptoms== | ||
60 percent of [[adrenocortical carcinoma]] (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.<ref name="pmid16551738">{{cite journal| author=Allolio B, Fassnacht M| title=Clinical review: Adrenocortical carcinoma: clinical update. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 6 | pages= 2027-37 | pmid=16551738 | doi=10.1210/jc.2005-2639 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16551738 }}</ref> | 60 percent of [[adrenocortical carcinoma]] (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.<ref name="pmid16551738">{{cite journal| author=Allolio B, Fassnacht M| title=Clinical review: Adrenocortical carcinoma: clinical update. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 6 | pages= 2027-37 | pmid=16551738 | doi=10.1210/jc.2005-2639 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16551738 }}</ref> | ||
* | * 45% of ACCs show symptoms of [[Cushing's syndrome]] alone | ||
* | * 25% present with mixed overproduction of both [[glucocorticoids]] and [[androgens]].<ref name="pmid10679640">{{cite journal| author=Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA et al.| title=Adrenocortical carcinoma: clinical and laboratory observations. | journal=Cancer | year= 2000 | volume= 88 | issue= 4 | pages= 711-36 | pmid=10679640 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10679640 }}</ref> | ||
* | * 10% present with [[virilization]] alone | ||
(a) Symptoms of [[glucocorticoid]] excess include:<ref>{{Cite journal | |||
| author = [[Bibek Bista]] & [[Nancy Beck]] | | author = [[Bibek Bista]] & [[Nancy Beck]] | ||
| Line 27: | Line 27: | ||
*[[Insomnia]] | *[[Insomnia]] | ||
(b) Symptoms of [[androgen]] excess symptoms in women include:<ref>{{Cite journal | |||
| author = [[Lourdes Ibanez]], [[Ken K. Ong]], [[Abel Lopez-Bermejo]], [[David B. Dunger]] & [[Francis de Zegher]] | | author = [[Lourdes Ibanez]], [[Ken K. Ong]], [[Abel Lopez-Bermejo]], [[David B. Dunger]] & [[Francis de Zegher]] | ||
| Line 43: | Line 43: | ||
*[[Acne]] | *[[Acne]] | ||
*Deepening of the voice | *Deepening of the voice | ||
*Coarsening of facial features | *Coarsening of [[facial]] features | ||
*[[Amenorrhea|Cessation of menstruation]] | *[[Amenorrhea|Cessation of menstruation]] | ||
3- Symptoms of [[mineralcorticoid|mineralocorticoid]] excess include:<ref>{{Cite journal | 3- Symptoms of [[mineralcorticoid|mineralocorticoid]] excess include:<ref>{{Cite journal | ||
| Line 62: | Line 62: | ||
*[[Confusion]] | *[[Confusion]] | ||
*[[Palpitations]] | *[[Palpitations]] | ||
4- Symptoms of [[estrogen]] excess | 4- Symptoms of [[estrogen]] excess in men) include:<ref>{{Cite journal | ||
| author = [[G. M. Zanetta]], [[M. J. Webb]], [[H. Li]] & [[G. L. Keeney]] | | author = [[G. M. Zanetta]], [[M. J. Webb]], [[H. Li]] & [[G. L. Keeney]] | ||
| Line 86: | Line 86: | ||
6- Other symptoms may include:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1</ref> | 6- Other symptoms may include:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1</ref> | ||
*[[Abdominal mass|Abdominal lump]] | *[[Abdominal mass|Abdominal lump]] | ||
*Abdominal or [[back pain]] | *[[Abdominal]] or [[back pain]] | ||
*Abdominal fullness | *Abdominal fullness | ||
7- Children usually present with [[virilization]] (84%), while isolated [[glucocorticoid]] excess is much less common (6%).<ref name="pmid15137014">{{cite journal| author=Stewart JN, Flageole H, Kavan P| title=A surgical approach to adrenocortical tumors in children: the mainstay of treatment. | journal=J Pediatr Surg | year= 2004 | volume= 39 | issue= 5 | pages= 759-63 | pmid=15137014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15137014 }}</ref> | 7- Children usually present with [[virilization]] (84%), while isolated [[glucocorticoid]] excess is much less common (6%).<ref name="pmid15137014">{{cite journal| author=Stewart JN, Flageole H, Kavan P| title=A surgical approach to adrenocortical tumors in children: the mainstay of treatment. | journal=J Pediatr Surg | year= 2004 | volume= 39 | issue= 5 | pages= 759-63 | pmid=15137014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15137014 }}</ref> | ||
Revision as of 15:36, 29 September 2017
|
Adrenocortical carcinoma Microchapters |
|
Differentiating Adrenocortical carcinoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Study |
|
Adrenocortical carcinoma history and symptoms On the Web |
|
American Roentgen Ray Society Images of Adrenocortical carcinoma history and symptoms |
|
Risk calculators and risk factors for Adrenocortical carcinoma history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]
Overview
Symptoms of adrenocortical carcinoma include symptoms of androgen, glucocorticoid, mineralocorticoid, or estrogen excess. Symptoms of glucocorticoid excess include Weight gain, Acne, irritability. Symptoms of androgen excess include hirsutism, acne, and deepening of the voice. Symptoms of mineralocorticoid excess include headache, muscle weakness, Confusion, and palpitations.
Common Symptoms
60 percent of adrenocortical carcinoma (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.[1]
- 45% of ACCs show symptoms of Cushing's syndrome alone
- 25% present with mixed overproduction of both glucocorticoids and androgens.[2]
- 10% present with virilization alone
(a) Symptoms of glucocorticoid excess include:[3]
(b) Symptoms of androgen excess symptoms in women include:[4]
- Excess facial and body hair
- Acne
- Deepening of the voice
- Coarsening of facial features
- Cessation of menstruation
3- Symptoms of mineralocorticoid excess include:[5]
4- Symptoms of estrogen excess in men) include:[6]
- Gynecomastia
- Decreased libido
- Impotence
5- symptoms of catecholamines excess has been reported in adrenocortical cancers:[7]
6- Other symptoms may include:[8]
- Abdominal lump
- Abdominal or back pain
- Abdominal fullness
7- Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%).[9]
References
- ↑ Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. doi:10.1210/jc.2005-2639. PMID 16551738.
- ↑ Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA; et al. (2000). "Adrenocortical carcinoma: clinical and laboratory observations". Cancer. 88 (4): 711–36. PMID 10679640.
- ↑ Bibek Bista & Nancy Beck (2014). "Cushing syndrome". Indian journal of pediatrics. 81 (2): 158–164. doi:10.1007/s12098-013-1203-8. PMID 24062268. Unknown parameter
|month=ignored (help) - ↑ Lourdes Ibanez, Ken K. Ong, Abel Lopez-Bermejo, David B. Dunger & Francis de Zegher (2014). "Hyperinsulinaemic androgen excess in adolescent girls". Nature reviews. Endocrinology. 10 (8): 499–508. doi:10.1038/nrendo.2014.58. PMID 24776733. Unknown parameter
|month=ignored (help) - ↑ Valeria Bisogni, Gian Paolo Rossi & Lorenzo A. Calo (2014). "Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology". Blood pressure. 23 (3): 189–192. doi:10.3109/08037051.2013.832967. PMID 24053336. Unknown parameter
|month=ignored (help) - ↑ G. M. Zanetta, M. J. Webb, H. Li & G. L. Keeney (2000). "Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis". Gynecologic oncology. 79 (1): 18–22. doi:10.1006/gyno.2000.5905. PMID 11006024. Unknown parameter
|month=ignored (help) - ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1
- ↑ Stewart JN, Flageole H, Kavan P (2004). "A surgical approach to adrenocortical tumors in children: the mainstay of treatment". J Pediatr Surg. 39 (5): 759–63. PMID 15137014.