Hemolytic anemia differential diagnosis: Difference between revisions
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{| class="wikitable" | {| class="wikitable" | ||
! scope="col" | Characteristic/Parameter | ! scope="col" | Characteristic/Parameter | ||
! scope="col" | ''' | ! scope="col" | '''Hemolytic anemia''' | ||
! scope="col" | ''' | ! scope="col" | '''Sideroblastic anemia''' | ||
! scope="col" | ''' | ! scope="col" | '''Anemia of chronic disease''' | ||
! scope="col" | ''' | ! scope="col" | '''Thalassemia''' | ||
! scope="col" | ''' | ! scope="col" | '''Iron-deficiency anemia''' | ||
! scope="col" | ''' | ! scope="col" | '''Erythropoietin deficiency''' | ||
! scope="col" | ''' | ! scope="col" | '''Vitamin B12 deficiency''' | ||
! scope="col" | '''Folate deficiency''' | |||
|- | |- | ||
! scope="row" | Symptoms | ! scope="row" | Symptoms | ||
| Line 24: | Line 25: | ||
| [[Petechiae]], [[bleeding]], other [[autoimmune diseases]] | | [[Petechiae]], [[bleeding]], other [[autoimmune diseases]] | ||
| [[Petechia]]<nowiki/>e, [[purpura]], [[ecchymoses]] | | [[Petechia]]<nowiki/>e, [[purpura]], [[ecchymoses]] | ||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | |||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | | [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | ||
|- | |- | ||
| Line 34: | Line 36: | ||
| Low; can be less than 10000 per microliter; sudden onset after [[transfusion]] | | Low; can be less than 10000 per microliter; sudden onset after [[transfusion]] | ||
| Variable; usually low | | Variable; usually low | ||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | |||
|- | |- | ||
! scope="row" | PT and PTT | ! scope="row" | PT and PTT | ||
| Line 43: | Line 46: | ||
| Normal | | Normal | ||
| Usually normal | | Usually normal | ||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | |||
|- | |- | ||
! scope="row" | Etiology | ! scope="row" | Etiology | ||
| Line 52: | Line 56: | ||
| Exposure to transfused products | | Exposure to transfused products | ||
| Autoimmunity with development of [[antibodies]] to [[DNA]] | | Autoimmunity with development of [[antibodies]] to [[DNA]] | ||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | |||
|- | |- | ||
! scope="row" | Drug-related | ! scope="row" | Drug-related | ||
| Line 61: | Line 66: | ||
| No; transfusion-related | | No; transfusion-related | ||
| Possible; drug-induced lupus can be caused by medications like [[hydralazine]] or [[isoniazid]] | | Possible; drug-induced lupus can be caused by medications like [[hydralazine]] or [[isoniazid]] | ||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | |||
|- | |- | ||
! scope="row" | Bleeding | ! scope="row" | Bleeding | ||
| Line 70: | Line 76: | ||
| Yes; spontaneous bleeding if platelet count < 10000 per microliter | | Yes; spontaneous bleeding if platelet count < 10000 per microliter | ||
| Rare | | Rare | ||
| [[Bleeding]], [[photosensitivity]], [[arthritis]], [[malar rash]], discoid rash, [[Renal insufficiency|renal failure]], [[seizures]], [[psychosis]] | |||
|} | |} | ||
Revision as of 02:38, 3 October 2017
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Hemolytic anemia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Hemolytic anemia differential diagnosis On the Web |
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American Roentgen Ray Society Images of Hemolytic anemia differential diagnosis |
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Risk calculators and risk factors for Hemolytic anemia differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Differentiating Hemolytic anemia from other Diseases
| Characteristic/Parameter | Hemolytic anemia | Sideroblastic anemia | Anemia of chronic disease | Thalassemia | Iron-deficiency anemia | Erythropoietin deficiency | Vitamin B12 deficiency | Folate deficiency |
|---|---|---|---|---|---|---|---|---|
| Symptoms | Bleeding, thrombosis, skin necrosis | Bleeding, thrombosis, petechiae, sepsis | Renal failure, hematuria, bleeding, microangiopathic hemolytic anemia | Renal failure, hematuria, bleeding, microangiopathic hemolytic anemia | Petechiae, bleeding, other autoimmune diseases | Petechiae, purpura, ecchymoses | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis |
| Platelet count | Low but usually more than 20000 per microliter | Low | Low | Low | Low; can be as low as 10000 per microliter | Low; can be less than 10000 per microliter; sudden onset after transfusion | Variable; usually low | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis |
| PT and PTT | Normal | Elevated | Normal | Normal | Normal | Normal | Usually normal | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis |
| Etiology | Heparin exposure | Sepsis, delivery of fetus, acute promyelocytic leukemia, other malignancy | E.coli strain O157:H7; Shiga-like toxin | Dysregulation of complement activation; mutation in complement factor H | Idiopathic; can be secondary to chronic lymphocytic leukemia, HIV, viral hepatitis, H. pylori | Exposure to transfused products | Autoimmunity with development of antibodies to DNA | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis |
| Drug-related | Yes, always | Possible | No | No | Yes | No; transfusion-related | Possible; drug-induced lupus can be caused by medications like hydralazine or isoniazid | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis |
| Bleeding | Possible | Usually | Usually | Usually | Yes; spontaneous bleeding if platelet count < 10000 per microliter | Yes; spontaneous bleeding if platelet count < 10000 per microliter | Rare | Bleeding, photosensitivity, arthritis, malar rash, discoid rash, renal failure, seizures, psychosis |