Autoimmune polyendocrine syndrome laboratory findings

Autoimmune polyendocrine syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Autoimmune polyendocrine syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic study of choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Autoimmune polyendocrine syndrome laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Autoimmune polyendocrine syndrome laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Autoimmune polyendocrine syndrome laboratory findings
CDC on Autoimmune polyendocrine syndrome laboratory findings
Autoimmune polyendocrine syndrome laboratory findings in the news
Blogs on Autoimmune polyendocrine syndrome laboratory findings
Directions to Hospitals Treating Autoimmune polyendocrine syndrome
Risk calculators and risk factors for Autoimmune polyendocrine syndrome laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/ot

OR

Laboratory findings suggestive with the diagnosis of autoimmune polyendocrine syndrome (APS) include testing for the presence of autoantibodies(serology) followed by functional testing. Patients are tested for autoantibodies against 21-hydroxylase, 17-hydroxylase glutamic acid decarboxylase (GAD), islet cell antibodies, thyroid peroxidase (TPO), TSH receptor and thyroid-stimulating immunoglobulins (TSI). Other tests include thyroid function test, adrenal function test, electrolytes, blood glucose, CBC and Vitamin B12.

Laboratory Findings

Laboratory findings suggestive with the diagnosis of autoimmune polyendocrine syndrome (APS) include testing for the presence of autoantibodies(serologic measurement) followed by functional testing. Antibodies against the following proteins are tested:

• 21-hydroxylase and 17-hydroxylase
• Glutamic acid decarboxylase (GAD) and islet cell antibodies
• Thyroid peroxidase (TPO), TSH receptor and thyroid-stimulating immunoglobulins (TSI).
• Ca+ sensitive receptor
• Parietal cell and anti-intrinsic factor
• Transglutaminase gliadin
• Tyrosine Hydroxylase and Tyrosinase

Other test include:

Name of laboratory test	Findings suggestive of abnormality
Complete blood count (CBC)	Lymphocytosis Neutropenia Anemia Increased MCV
CD4 count and HIV testing	CD4 count may be Normal/↓
Pottasium hydroxide test	May show fungal infection
Electrolytes	Hyponatremia Hyperkalemia Mild metabolic acidosis Azotemia
Complete metabolic profile	Hypocalcemia Hyperphosphatemia Hypomagnesemia
Adrenal function test	↑ ACTH ↑ Plasma renin activity Abnormal cosyntropin stimulation
Thyroid function test	↑ TSH ↓  free T4 and T3 ↑ Thyrotropin
Blood Glucose test	↑ Fasting blood glucose ↑ HbA1c
Vitamin B12 level	Normal/↓