Pheochromocytoma risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The most potent risk factor for pheochromocytoma is a family history of [[Multiple endocrine neoplasia|multiple endocrine neoplasias,]] [[Von Hippel-Lindau disease]], [[Neurofibromatosis type I|neurofibromatosis type 1]], [[Paraganglioma|hereditary paraganglioma syndromes]]. | |||
==Risk Factors== | ==Risk Factors== | ||
Revision as of 00:27, 25 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
The most potent risk factor for pheochromocytoma is a family history of multiple endocrine neoplasias, Von Hippel-Lindau disease, neurofibromatosis type 1, hereditary paraganglioma syndromes.
Risk Factors
The most potent risk factors of pheochromocytoma are:
Age
- Occurs in third decade of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.[1]
- Hereditary tumors present at a younger age than sporadic.
Family history
Ten percent of pheochromocytomas are linked to hereditary causes:
| MEN1 | MEN2 |
|---|---|
- Von Hippel-Lindau disease can result in tumors at multiple sites, including the central nervous system, endocrine system, pancreas and kidneys.
- Neurofibromatosis 1 results in multiple tumors in the skin (neurofibromas), pigmented skin spots and tumors of the optic nerve.
- Hereditary paraganglioma syndromes are inherited disorders that result in either pheochromocytomas or paragangliomas.
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc